TTC4 Antibody (F-8): sc-377329

TTC4 Antibody (F-8) is a mouse monoclonal IgM antibody that detects TTC4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TTC4 antibody (F-8) is available as the non-conjugated form. TTC4, also known as tetratricopeptide repeat domain 4, is a 387 amino acid nucleoplasmic protein that plays a crucial role in cellular processes by mediating protein-protein interactions through tetratricopeptide repeat (TPR) motifs. These motifs consist of a degenerate 34 amino acid sequence that can form up to 16 tandem repeats, each adopting a helix-turn-helix structure that contributes to ligand binding specificity. TTC4 is primarily localized in the cytoplasm and translocates to the nucleus with MSL-1 during the G1 and S phases of the cell cycle, highlighting TTC4′s importance in cell cycle regulation. TTC4 interacts with several key proteins, including heat shock proteins HSP 90 and HSP 70, as well as the replication protein Cdc6, suggesting TTC4′s involvement in the progression of malignant melanoma. The gene encoding TTC4 is located on human chromosome 1, which spans approximately 260 million base pairs and comprises nearly 8% of the human genome, underscoring TTC4′s significance in various biological contexts.

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TTC4 Antibody (F-8) References:

1. Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.  |  Su, G., et al. 2000. Int J Mol Med. 5: 197-200. PMID: 10639601
2. Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14-->p13 by in situ hybridization.  |  Hey, Y., et al. 2000. Cytogenet Cell Genet. 88: 272-4. PMID: 10828607
3. TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin.  |  Poetsch, M., et al. 2000. Oncogene. 19: 5817-20. PMID: 11126369
4. Lack of TTC4 mutations in melanoma.  |  Irwin, N., et al. 2002. J Invest Dermatol. 119: 186-7. PMID: 12164943
5. Tetratricopeptide repeats of Tfc4 and a limiting step in the assembly of the initiation factor TFIIIB.  |  Moir, RD. and Willis, IM. 2004. Adv Protein Chem. 67: 93-121. PMID: 14969725
6. Characterization of hampin/MSL1 as a node in the nuclear interactome.  |  Dmitriev, RI., et al. 2007. Biochem Biophys Res Commun. 355: 1051-7. PMID: 17335777
7. The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.  |  Crevel, G., et al. 2008. PLoS One. 3: e0001737. PMID: 18320024
8. Nuclear transport of protein TTC4 depends on the cell cycle.  |  Dmitriev, RI., et al. 2009. Cell Tissue Res. 336: 521-7. PMID: 19390865
9. TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer.  |  Su, G., et al. 1999. Genomics. 55: 157-63. PMID: 9933562

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TTC4 Antibody (F-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TTC4 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TTC4 Antibody (F-8) Specifications

Alternate Product Name: TTC4

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 13-47

Epitope Target: TTC4

Epitope Species: human

Product Reactivity/Detection: TTC4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TTC4 Antibody (F-8): P: Blocking Peptide