TSHR Antibody (C-10): sc-515556

TSHR Antibody (C-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects thyroid-stimulating hormone receptor (TSHR) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TSHR antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TSHR is a glycoprotein that plays a crucial role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH), which is essential for maintaining thyroid structure and metabolism. TSHR is located on the surface of thyroid follicular cells, where TSH binding leads to the activation of intracellular signaling pathways that stimulate the production and release of thyroid hormones. Such regulation is vital for numerous physiological processes, including metabolism, growth, and development. TSHR undergoes post-translational modifications, such as glycosylation, which are important for stability, localization, and function. These modifications can influence receptor activity and are critical for proper signaling, highlighting TSHR′s importance in endocrine health. In conditions like Graves′ disease, autoantibodies can activate TSHR, leading to hyperthyroidism, underscoring TSHR′s significance in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TSHR Antibody (C-10) References:

1. Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis.  |  Endo, T. and Kobayashi, T. 2008. Am J Physiol Endocrinol Metab. 295: E514-8. PMID: 18559984
2. GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.  |  Kang, HS., et al. 2017. J Clin Invest. 127: 4326-4337. PMID: 29083325
3. Correlation of thyroid stimulating hormone receptor mRNA expression levels in peripheral blood with undesirable clinicopathological features in papillary thyroid carcinoma patients.  |  Liu, R., et al. 2017. Oncotarget. 8: 74129-74138. PMID: 29088773
4. Thyroid-stimulating hormone receptor antibodies during follow-up as remission markers in childhood-onset Graves' disease treated with antithyroid drugs.  |  Wang, SY., et al. 2020. Kaohsiung J Med Sci. 36: 281-286. PMID: 31849168
5. TSHRV656F Activating Variant of the Thyroid Stimulating Hormone Receptor Gene in Neonatal Onset Hyperthyroidism: A Case Review.  |  Kayaş, L., et al. 2022. J Clin Res Pediatr Endocrinol. 14: 114-118. PMID: 33443352
6. Differentiation of benign thyroid nodules from malignant thyroid nodules through miR-205-5p and thyroid-stimulating hormone receptor mRNA.  |  Zhou, J., et al. 2021. Hormones (Athens). 20: 571-580. PMID: 33788150
7. TSH-TSHR axis promotes tumor immune evasion.  |  Wu, Z., et al. 2022. J Immunother Cancer. 10: PMID: 35101946
8. Analysis of structure-activity and structure-mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging the ToxCast library.  |  Sahoo, AK., et al. 2023. RSC Adv. 13: 23461-23471. PMID: 37546222
9. TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.  |  Li, Y., et al. 2024. Biochem Biophys Res Commun. 704: 149723. PMID: 38430698
10. Low-molecular-weight Ligand of the Thyroid-stimulating Hormone Receptor with the Activity of a Partial Agonist and a Negative Allosteric Modulator.  |  Derkach, KV., et al. 2025. Dokl Biochem Biophys.. PMID: 39847295

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSHR Antibody (C-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TSHR Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSHR Antibody (C-10) Specifications

Alternate Product Name: Thyroid Stimulating Hormone Receptor

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 45-67

Epitope Target: TSHR

Epitope Species: human

Product Reactivity/Detection: full length and A subunit TSHR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TSHR Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred TSHR antibody is TSHR Antibody (3B12): sc-53542.