TSHR Activators
TSHR (Thyroid-Stimulating Hormone Receptor) Activators belong to a distinctive chemical class that plays a crucial role in regulating the thyroid gland's function within the endocrine system. The thyroid gland, a butterfly-shaped organ located in the neck, produces hormones that are essential for maintaining overall metabolic homeostasis in the body. TSHR activators are compounds that interact with the TSHR, a G-protein-coupled receptor situated on the surface of thyroid follicular cells. This interaction triggers a cascade of intracellular events that ultimately lead to the activation of the thyroid gland.
TSHR activators typically comprise small molecules or ligands that bind to the TSHR with high affinity. Upon binding, these activators induce conformational changes in the receptor, which in turn lead to the activation of intracellular signaling pathways, primarily the cyclic AMP (cAMP) pathway. Activation of this pathway results in increased production and secretion of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3), into the bloodstream. These hormones are essential for various physiological processes, including metabolism, growth, and development. TSHR activators are pivotal in the feedback loop that regulates thyroid hormone production; when thyroid hormone levels drop, the pituitary gland releases thyroid-stimulating hormone (TSH), which then binds to TSHR and activates it, stimulating the thyroid gland to produce more hormones.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may increase cAMP levels in thyroid follicular cells, potentially enhancing TSHR expression through the activation of protein kinase A. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence thyroid function and potentially upregulate TSHR expression via retinoic acid receptors. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium has been shown to affect thyroid function, possibly by modulating TSHR expression, though the exact mechanism is unclear. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3 may induce a feedback mechanism, altering TSHR expression levels to maintain thyroid hormone homeostasis. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an oxidative stress agent, hydrogen peroxide can alter cellular functions and may influence TSHR expression levels in the thyroid. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
DbcAMP is a cAMP analog that can mimic the action of TSH, potentially leading to the upregulation of TSHR expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can influence thyroid function and may have an indirect role in modulating TSHR expression. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Glucagon, like insulin, plays a role in metabolism and may also influence thyroid function and TSHR expression. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is essential for thyroid function, and selenium dioxide may contribute to the regulation of TSHR expression. | ||||||