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Insulin 항체 () (CAS 11061-68-0)

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대체 이름:
Recombinant Human Insulin; rh-Insulin
적용:
Insulin 는 <대장균>에서 생성되는 분자입니다.
CAS 등록번호:
11061-68-0
분자량:
5807
분자식:
C257H383N65O77S6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

빠른 링크

인슐린은 주로 포도당의 세포 내 흡수를 촉진하여 신진대사에 중요한 역할을 하는 펩타이드 호르몬입니다. 과학 연구에서 인슐린은 세포 포도당 흡수에 대한 작용 메커니즘과 광범위한 신진대사 효과에 대해 광범위하게 연구되고 있습니다. 특히 인슐린은 세포 표면의 인슐린 수용체에 결합하여 일련의 세포 내 신호 전달을 촉발합니다. 이 신호 전달 경로는 인슐린 수용체 기질(IRS)과 포스파티딜이노시톨 3-키나아제(PI3K)의 활성화로 이어져 포도당 수송체 4형(GLUT4) 소포가 세포막으로 이동하여 포도당 흡수를 촉진하는 과정을 포함합니다. 인슐린은 고전적인 대사 역할 외에도 세포 성장과 분화에도 영향을 미치며, 이는 현재 활발히 연구되고 있는 분야입니다. 이 호르몬은 유전자 발현과 세포 주기 진행에 영향을 미치는 라스 미토겐 활성화 단백질 키나아제(MAPK) 경로를 비롯한 여러 신호 전달 경로를 활성화하는 것으로 밝혀졌습니다. 신진대사와 세포 조절 모두에서 인슐린의 이러한 이중 역할은 대사 신호와 미토겐 신호의 통합을 연구하는 데 유용한 모델을 제공합니다.


Insulin 항체 () (CAS 11061-68-0) 참고자료

  1. A new approach to characterization of insulin derived from different species using 1H-NMR coupled with multivariate analysis.  |  Ohno, A., et al. 2012. Chem Pharm Bull (Tokyo). 60: 320-4. PMID: 22382411
  2. A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel.  |  Sun, Y., et al. 2019. Anal Chim Acta. 1089: 152-164. PMID: 31627812
  3. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.  |  Gu, L., et al. 2019. Int J Biol Sci. 15: 2815-2829. PMID: 31853220
  4. Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats.  |  Quarta, E., et al. 2020. J Control Release. 323: 412-420. PMID: 32325175
  5. Injectable Silk Fibroin-Based Hydrogel for Sustained Insulin Delivery in Diabetic Rats.  |  Maity, B., et al. 2020. ACS Appl Bio Mater. 3: 3544-3552. PMID: 35025224
  6. Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities.  |  Rujanapun, N., et al. 2022. Front Pharmacol. 13: 797032. PMID: 35321328
  7. Comparative microelectrode array data of the functional development of hPsc-derived and rat neuronal networks.  |  Kapucu, FE., et al. 2022. Sci Data. 9: 120. PMID: 35354837
  8. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme.  |  Distefano, A., et al. 2022. Anal Bioanal Chem. 414: 4793-4802. PMID: 35577931
  9. Formation of subvisible particles in commercial insulin formulations.  |  Silva-Jr, H., et al. 2022. Colloids Surf B Biointerfaces. 216: 112566. PMID: 35623256
  10. Increased disulfide peptide sequence coverage via "cleavage ON/OFF" switch during nanoelectrospray  |  Gongyu Li, et al. 2014. RSC Advances. 4.103: 59650-59654.

주문정보

제품명카탈로그 번호 단위가격수량관심품목

Insulin, 100 mg

sc-29062
100 mg
$153.00

Insulin, 1 g

sc-29062A
1 g
$1224.00

Insulin, 10 g

sc-29062B
10 g
$12239.00

Does it work with rat skeletal L6 cells?

Asked by: AiChiF
Thank you for your question. We have not validated Insulin to work on rat skeletal L6 cells.
Answered by: BlakeJ
Date published: 2023-10-10

Is sc-29062, Insulin soluble in PBS? or water?

Asked by: Jz28sail
Thank you for your question. Getting recombinant insulin into solution isn't easy, and requires titration with HCl. It is recommended to reconstitute the lyophilized Insulin in sterile 0.005N HCl not more than 1 mg/ml. Our Human Insulin solution (sc-360248) works very well and has been recommended by the Chemicals Department as an alternative due to the difficulty of getting recombinant insulin into solution. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2018-04-02
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Rated 5 out of 5 by from OthmanOthman, et. al. (PubMed ID 24355212) used product sc-29062 in his study to describe the mechanism by which insulin can cause oxidative stress and serious downstream problems (start or support the progression of carcinogenesis in diabetic patients). -SCBT Publication Review
Date published: 2015-06-26
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Insulin 항체 () is rated 5.0 out of 5 by 1.
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