TSHR Antibody (A10): sc-57489
- TSHR Antibody (A10) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 22-35 of TSHR of human origin
- recommended for detection of TSHR of human and porcine origin by WB, IP and IF
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TSHR Antibody (A10) for WB applications. These reagents are now offered in bundles with TSHR Antibody (A10) (see ordering information below).
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TSHR Antibody (A10) is a mouse monoclonal IgG2b antibody that detects thyroid-stimulating hormone receptor (TSHR) in human and porcine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TSHR is a critical glycoprotein located on the surface of thyroid follicular cells, where TSHR plays a vital role in regulating thyroid hormone synthesis and secretion. TSHR activation by thyroid-stimulating hormone leads to a cascade of intracellular signaling events that ultimately influence metabolic processes and growth. TSHR is involved in the regulation of inositol phosphate and cyclic adenosine monophosphate (cAMP) formation, which are essential for maintaining normal thyroid function. Dysregulation of TSHR signaling can result in various thyroid disorders, including Graves′ disease, where autoantibodies mistakenly activate TSHR, leading to hyperthyroidism. Anti-TSHR antibody (A10) is an invaluable tool for researchers studying thyroid function and related pathologies, providing insights into the mechanisms of receptor activation and the impact of post-translational modifications on receptor activity.
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TSHR Antibody (A10) References:
- New insights into the thyroid-stimulating hormone receptor. The major antigen of Graves' disease. | Graves, PN. and Davies, TF. 2000. Endocrinol Metab Clin North Am. 29: 267-86, vi. PMID: 10874529
- Molecular basis for the autoreactivity against thyroid stimulating hormone receptor. | Kohn, LD., et al. 1992. Int Rev Immunol. 9: 135-65. PMID: 1283175
- Thyroid-stimulating hormone receptor and its role in Graves' disease. | Chistiakov, DA. 2003. Mol Genet Metab. 80: 377-88. PMID: 14654350
- Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. | Brand, OJ., et al. 2009. Hum Mol Genet. 18: 1704-13. PMID: 19244275
- Constitutive activation of the thyroid-stimulating hormone receptor (TSHR) by mutating Ile691 in the cytoplasmic tail segment. | Liu, Z., et al. 2011. PLoS One. 6: e16335. PMID: 21283701
- Thyroid-stimulating hormone receptor activity after internalization. | Calebiro, D. 2011. Ann Endocrinol (Paris). 72: 64-7. PMID: 21511242
- Differential transcriptional and protein expression of thyroid-stimulating hormone receptor in ovarian carcinomas. | Gyftaki, R., et al. 2014. Int J Gynecol Cancer. 24: 851-6. PMID: 24844218
- Bipolar limbic expression of auto-immune thyroid targets: thyroglobulin and thyroid-stimulating hormone receptor. | Naicker, M., et al. 2019. Metab Brain Dis. 34: 1281-1298. PMID: 31197680
- Serum thyroid-stimulating hormone receptor antibody levels and thyroid dysfunction after hysterosalpingography: a case-control study. | So, S., et al. 2021. Gynecol Endocrinol. 37: 898-901. PMID: 34355625
- Cellular and molecular distribution of thyroid-specific proteins, thyroid-stimulating hormone receptor (TSH-R) and thyroglobulin (TG) in the central nervous system. | Naicker, M. and Naidoo, S. 2022. Neurochem Int. 155: 105305. PMID: 35181395
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSHR Antibody (A10) | sc-57489 | 200 µg/ml | $322.00 | |||
TSHR Antibody (A10): m-IgG Fc BP-HRP Bundle | sc-537138 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (A10): m-IgGκ BP-HRP Bundle | sc-534331 | 200 µg Ab; 40 µg BP | $361.00 |