TSHR Antibody (5G225): sc-73241
- TSHR Antibody (5G225) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against an extracellular domain of TSHR of human origin, epitope mapping to amino acids 381-384
- recommended for detection of TSHR of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TSHR Antibody (5G225) for WB applications. These reagents are now offered in bundles with TSHR Antibody (5G225) (see ordering information below).
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TSHR Antibody (5G225) is a mouse monoclonal IgG2a antibody that detects thyroid-stimulating hormone receptor (TSHR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TSHR is a critical glycoprotein located on the surface of thyroid follicular cells, where TSHR plays a vital role in regulating thyroid hormone synthesis and secretion. TSHR activation by thyroid-stimulating hormone (TSH) initiates a cascade of intracellular signaling pathways that ultimately lead to the production of thyroid hormones, which are essential for maintaining metabolic homeostasis and overall physiological balance. TSHR (5G225) antibody is also valuable for studying various thyroid disorders, including Graves′ disease, where autoantibodies can aberrantly activate TSHR, leading to hyperthyroidism. Understanding the structure and function of TSHR is crucial for developing targeted therapies for these conditions, making anti-TSHR antibody (5G225) an invaluable tool for researchers studying thyroid function and related diseases.
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TSHR Antibody (5G225) References:
- Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. | Aghajanova, L., et al. 2011. Fertil Steril. 95: 230-7, 237.e1-2. PMID: 20691434
- The influence of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on osteoclastogenesis. | Ma, R., et al. 2011. Thyroid. 21: 897-906. PMID: 21745106
- Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). | Zhou, Q., et al. 2016. Tumour Biol. 37: 3105-13. PMID: 26427660
- TSHR as a therapeutic target in Graves' disease. | Smith, TJ. 2017. Expert Opin Ther Targets. 21: 427-432. PMID: 28127991
- Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease. | Diana, T., et al. 2017. Clin Exp Immunol. 189: 304-309. PMID: 28439882
- Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor. | Yang, J., et al. 2018. Sci Rep. 8: 4004. PMID: 29507327
- Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations. | Mon, SY., et al. 2018. Diagn Cytopathol. 46: 369-377. PMID: 29516685
- TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. | Duan, H., et al. 2023. Int Immunopharmacol. 124: 110873. PMID: 37690235
- Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice. | Eszlinger, M., et al. 2023. Eur Thyroid J. 12: PMID: 37855416
- The gene for the thyrotropin receptor (TSHR) as a candidate gene for congenital hypothyroidism with thyroid dysgenesis. | Krude, H., et al. 1996. Exp Clin Endocrinol Diabetes. 104 Suppl 4: 117-20. PMID: 8981017
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSHR Antibody (5G225) | sc-73241 | 200 µg/ml | $322.00 | |||
TSHR Antibody (5G225): m-IgG Fc BP-HRP Bundle | sc-537215 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (5G225): m-IgGκ BP-HRP Bundle | sc-534428 | 200 µg Ab; 40 µg BP | $361.00 | |||
TSHR Antibody (5G225): m-IgG2a BP-HRP Bundle | sc-547941 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (5G225) FITC | sc-73241 FITC | 200 µg/ml | $336.00 | |||
TSHR Antibody (5G225) PE | sc-73241 PE | 200 µg/ml | $349.00 |