TSHR Antibody (4C1): sc-32262
- TSHR Antibody (4C1) is a mouse monoclonal IgG2a κ, cited in 9 publications, provided at 200 µg/ml
- raised against an extracellular domain of TSHR of human origin, epitope mapping to amino acids 381-384
- recommended for detection of TSHR of human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TSHR Antibody (4C1). These reagents are now offered in bundles with TSHR Antibody (4C1) (see ordering information below).
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TSHR Antibody (4C1) is a mouse monoclonal IgG2a antibody that detects thyroid-stimulating hormone receptor (TSHR) in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-TSHR antibody (4C1) plays a crucial role in the study of thyroid function, as TSHR is a glycoprotein receptor located on the surface of thyroid cells, where TSHR mediates the effects of thyroid-stimulating hormone (TSH). The binding of TSH to TSHR initiates a cascade of intracellular signaling that regulates thyroid hormone synthesis and release, which is vital for maintaining metabolic homeostasis in the body. TSHR (4C1) monoclonal antibody enables research into various physiological processes, including growth, development, and metabolism, making TSHR a key target for understanding thyroid-related disorders. Dysregulation of TSHR signaling can lead to conditions such as Graves′ disease, where autoantibodies activate TSHR, resulting in hyperthyroidism. The structural integrity of TSHR, particularly the third cytoplasmic loop, is essential for TSHR function, as this region is involved in the regulation of inositol phosphate and cyclic AMP formation, further underscoring TSHR importance in endocrine signaling pathways.
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TSHR Antibody (4C1) References:
- Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies. | Davies, TF. and Latif, R. 2015. Expert Opin Ther Targets. 19: 835-47. PMID: 25768836
- Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease. | Stefan, M. and Faustino, LC. 2017. Front Endocrinol (Lausanne). 8: 57. PMID: 28421036
- Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance. | Bucci, I., et al. 2017. Front Endocrinol (Lausanne). 8: 137. PMID: 28713331
- Thyroid Stimulating Hormone Receptor Antibodies in Thyroid Eye Disease-Methodology and Clinical Applications. | Diana, T. and Kahaly, GJ. 2018. Ophthalmic Plast Reconstr Surg. 34: S13-S19. PMID: 29771755
- Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves' disease. | Holthoff, HP., et al. 2020. J Endocrinol. 246: 135-147. PMID: 32573180
- Antibodies against thyroid-stimulating hormone receptor cause maternal-neonatal transmission of Graves' Disease. | Yu, Y., et al. 2021. Exp Ther Med. 22: 1253. PMID: 34603521
- Expression of functional thyroid-stimulating hormone receptor in microglia. | Liu, Y., et al. 2022. Ann Endocrinol (Paris). 83: 40-45. PMID: 34896340
- Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy. | Taglietti, V., et al. 2023. Sci Transl Med. 15: eadd5275. PMID: 36857434
- Novel Antimurine Thyroid-Stimulating Hormone Receptor Monoclonal Antibodies. | Klee, AN., et al. 2023. Monoclon Antib Immunodiagn Immunother. 42: 109-114. PMID: 37343169
- Thyroid-stimulating hormone receptor (TSHR) as a target for imaging differentiated thyroid cancer. | Gimblet, GR., et al. 2024. Surgery. 175: 199-206. PMID: 37919223
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSHR Antibody (4C1) | sc-32262 | 200 µg/ml | $322.00 | |||
TSHR Antibody (4C1): m-IgG Fc BP-HRP Bundle | sc-536726 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (4C1): m-IgGκ BP-HRP Bundle | sc-533887 | 200 µg Ab; 40 µg BP | $361.00 | |||
TSHR Antibody (4C1): m-IgG2a BP-HRP Bundle | sc-547859 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (4C1) FITC | sc-32262 FITC | 200 µg/ml | $336.00 | |||
TSHR Antibody (4C1) PE | sc-32262 PE | 200 µg/ml | $349.00 |