TSHR Antibody (2C11): sc-32263
- TSHR Antibody (2C11) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against human recombinant GST-TSHR fusion protein, with epitope mapping to amino acids 352-362
- recommended for detection of TSHR of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TSHR Antibody (2C11) for WB and IHC(P) applications. These reagents are now offered in bundles with TSHR Antibody (2C11) (see ordering information below).
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TSHR Antibody (2C11) is a mouse monoclonal IgG1 antibody that detects thyroid-stimulating hormone receptor (TSHR) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-TSHR antibody (2C11) plays a crucial role in the study of thyroid function, as TSHR is primarily located on the surface of thyroid follicular cells, where TSHR mediates the effects of thyroid-stimulating hormone. TSHR (2C11) monoclonal antibody enables research on this essential receptor that regulates thyroid hormone synthesis and secretion, which are vital for maintaining metabolic homeostasis in the body. The binding of TSH to TSHR activates intracellular signaling pathways, including the production of cyclic adenosine monophosphate (cAMP), which subsequently influences gene expression and cellular activity. Dysregulation of TSHR signaling can lead to various thyroid disorders, including hyperthyroidism and hypothyroidism, making TSHR a significant target for therapeutic intervention. Understanding the localization and function of TSHR is critical for developing strategies to manage these conditions effectively.
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TSHR Antibody (2C11) References:
- The genetics of the thyroid stimulating hormone receptor: history and relevance. | Davies, TF., et al. 2010. Thyroid. 20: 727-36. PMID: 20578897
- Novel insights on thyroid-stimulating hormone receptor signal transduction. | Kleinau, G., et al. 2013. Endocr Rev. 34: 691-724. PMID: 23645907
- Thyroid-stimulating hormone receptor affects metastasis and prognosis in papillary thyroid carcinoma. | Liu, TR., et al. 2016. Eur Rev Med Pharmacol Sci. 20: 3582-91. PMID: 27649658
- Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis. | Zhang, ZZ., et al. 2017. Oncotarget. 8: 6623-6629. PMID: 28036261
- Biased signaling by thyroid-stimulating hormone receptor-specific antibodies determines thyrocyte survival in autoimmunity. | Morshed, SA., et al. 2018. Sci Signal. 11: PMID: 29363585
- The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. | Chu, YD. and Yeh, CT. 2020. Cells. 9: PMID: 32698392
- Expression and Purification of the Human Thyroid-Stimulating Hormone Receptor. | Helfinger, L. and Tate, CG. 2022. Methods Mol Biol. 2507: 313-325. PMID: 35773589
- Prognostic significance of thyroid-stimulating hormone receptor antibodies in moderate-to-severe graves' orbitopathy. | Park, J., et al. 2023. Front Endocrinol (Lausanne). 14: 1153312. PMID: 37223049
- Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment. | Gillis, A., et al. 2023. Mod Pathol. 36: 100332. PMID: 37716507
- Targeting Thyroid-Stimulating Hormone Receptor: A Perspective on Small-Molecule Modulators and Their Therapeutic Potential. | Zhang, Y., et al. 2024. J Med Chem. 67: 16018-16034. PMID: 39269788
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSHR Antibody (2C11) | sc-32263 | 200 µg/ml | $322.00 | |||
TSHR Antibody (2C11): m-IgG Fc BP-HRP Bundle | sc-536727 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSHR Antibody (2C11): m-IgGκ BP-HRP Bundle | sc-533888 | 200 µg Ab; 40 µg BP | $361.00 | |||
TSHR Antibody (2C11): m-IgG1 BP-HRP Bundle | sc-544785 | 200 µg Ab; 20 µg BP | $361.00 | |||
TSHR Antibody (2C11) FITC | sc-32263 FITC | 200 µg/ml | $336.00 | |||
TSHR Antibody (2C11) PE | sc-32263 PE | 200 µg/ml | $349.00 |