TSG-6 Antibody (E-1): sc-377277
- TSG-6 Antibody (E-1) is a mouse monoclonal IgG2b κ TSG-6 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 135-277 mapping at the C-terminus of TSG-6 of human origin
- TSG-6 Antibody (E-1) is recommended for detection of precursor and mature chain of TSG-6 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TSG-6 Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for TSG-6 Antibody (E-1) for WB and IHC(P) applications. These reagents are now offered in bundles with TSG-6 Antibody (E-1) (see ordering information below).
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TSG-6 Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect TSG-6, also known as TNF-stimulated gene 6 or TNFAIP6, in human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. TSG-6 is an essential extracellular glycoprotein involved in regulating inflammation and maintaining the stability of the extracellular matrix, making TSG-6 a critical factor in processes such as tissue repair, wound healing, and the progression of inflammatory diseases like rheumatoid arthritis. TSG-6 functions by interacting with hyaluronan and forming stable complexes with inter-α-inhibitor (IαI), which helps modulate the protease network and suppress excessive inflammatory responses. TSG-6 monoclonal antibody (E-1) targets an epitope located at amino acids 135-277 at the C-terminus of the human TSG-6 protein, ensuring high specificity and robust binding for accurate detection in various experimental settings. TSG-6 expression is rapidly induced by pro-inflammatory cytokines such as TNFα and IL-1, highlighting TSG-6′s pivotal role in immune responses and tissue remodeling. Post-translational modifications, particularly glycosylation, are crucial for proper folding, stability, and functional interactions of TSG-6, enhancing TSG-6′s ability to effectively regulate the extracellular environment. Anti-TSG-6 antibody (E-1) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing flexibility for diverse research applications. TSG-6 (E-1) antibody enables researchers to gain valuable insights into inflammation mechanisms and extracellular matrix dynamics, facilitating advancements in cellular biology, immunology, and related biomedical fields. TSG-6 (E-1) monoclonal antibody is an indispensable tool for investigating TSG-6′s structural and functional roles in both normal physiological processes and pathological conditions, thereby contributing to the development of therapeutic strategies for inflammatory diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSG-6 Antibody (E-1) | sc-377277 | 200 µg/ml | $322.00 | |||
TSG-6 Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-526092 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSG-6 Antibody (E-1): m-IgG2b BP-HRP Bundle | sc-549676 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSG-6 Antibody (E-1) AC | sc-377277 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TSG-6 Antibody (E-1) HRP | sc-377277 HRP | 200 µg/ml | $322.00 | |||
TSG-6 Antibody (E-1) FITC | sc-377277 FITC | 200 µg/ml | $336.00 | |||
TSG-6 Antibody (E-1) PE | sc-377277 PE | 200 µg/ml | $349.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 488 | sc-377277 AF488 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 546 | sc-377277 AF546 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 594 | sc-377277 AF594 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 647 | sc-377277 AF647 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 680 | sc-377277 AF680 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (E-1) Alexa Fluor® 790 | sc-377277 AF790 | 200 µg/ml | $364.00 |