Trx-2 Antibody (B-3): sc-137028

Trx-2 Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects Thioredoxin 2 (Trx-2) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Trx-2 is a small redox protein localized in the mitochondria, where Trx-2 plays a vital role in maintaining cellular health by scavenging reactive oxygen species (ROS) and regulating the mitochondrial apoptosis signaling pathway. This function is crucial as excessive ROS can lead to oxidative stress, which is implicated in numerous diseases, including neurodegenerative disorders and cancer. By modulating the redox state within mitochondria, Trx-2 helps to protect cells from apoptosis, thereby contributing to cell viability and overall organismal health. The interaction of Trx-2 with Trx reductases (TrxR1 and TrxR2) further underscores Trx-2′s importance, as these flavoproteins facilitate the reduction of oxidized Trx, ensuring a continuous supply of the active form. The potential therapeutic implications of targeting Trx-2 and associated pathways are significant, particularly in the context of developing treatments for conditions characterized by oxidative stress and mitochondrial dysfunction. Anti-Trx-2 antibody (B-3) is an essential tool for researchers investigating the role of this critical protein in cellular processes and disease mechanisms.

The preferred Trx-2 antibody is Trx-2 Antibody (F-10): sc-133201.