TrkB Antibody (H-8): sc-136990
- TrkB Antibody (H-8) is a mouse monoclonal IgG2b κ TrkB antibody, cited in 14 publications, provided at 200 µg/ml
- raised against amino acids 209-298 of Trk B of human origin
- TrkB Antibody (H-8) is recommended for detection of Trk B of human origin by WB, IP, IF and ELISA
- Anti-TrkB Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TrkB Antibody (H-8) for WB applications. These reagents are now offered in bundles with TrkB Antibody (H-8) (see ordering information below).
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Trk B Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody specifically designed to detect Trk B, also known as NTRK2, in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Trk B antibody (H-8) targets an epitope encompassing amino acids 209-298 of the human Trk B protein, ensuring precise binding to this critical region. Trk B is a member of the tropomyosin receptor kinase family and functions as a vital tyrosine kinase receptor for neurotrophic factors including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). These interactions are essential for the development, maintenance, and function of the central and peripheral nervous systems, influencing processes such as neuronal survival, differentiation, and synaptic plasticity. Post-translational modifications, particularly the phosphorylation of tyrosine residues on Trk B, play a crucial role in activating the receptor and facilitating downstream signaling pathways that regulate these cellular functions. The phosphorylation of Trk B enhances its ability to interact with various signaling molecules, thereby modulating complex cellular responses to neurotrophic signals. By enabling the detection of both the unmodified and phosphorylated forms of Trk B, Trk B (H-8) antibody allows researchers to investigate the dynamic regulation of Trk B activity and its involvement in neurological disorders. Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants, Trk B monoclonal antibody (H-8) offers versatility for diverse experimental needs. Anti-Trk B antibody (H-8) is recommended for scientists studying the molecular mechanisms of neurodevelopment and for the development of therapeutic strategies targeting Trk B in various neurological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TrkB Antibody (H-8) | sc-136990 | 200 µg/ml | $322.00 | |||
TrkB Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-521384 | 200 µg Ab, 40 µg BP | $361.00 | |||
TrkB Antibody (H-8): m-IgG2b BP-HRP Bundle | sc-548886 | 200 µg Ab; 10 µg BP | $361.00 | |||
TrkB Antibody (H-8) AC | sc-136990 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TrkB Antibody (H-8) HRP | sc-136990 HRP | 200 µg/ml | $322.00 | |||
TrkB Antibody (H-8) FITC | sc-136990 FITC | 200 µg/ml | $336.00 | |||
TrkB Antibody (H-8) PE | sc-136990 PE | 200 µg/ml | $349.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 488 | sc-136990 AF488 | 200 µg/ml | $364.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 546 | sc-136990 AF546 | 200 µg/ml | $364.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 594 | sc-136990 AF594 | 200 µg/ml | $364.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 647 | sc-136990 AF647 | 200 µg/ml | $364.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 680 | sc-136990 AF680 | 200 µg/ml | $364.00 | |||
TrkB Antibody (H-8) Alexa Fluor® 790 | sc-136990 AF790 | 200 µg/ml | $364.00 |