Trk Antibody (MCTrks): sc-414
- Trk Antibody (MCTrks) is a mouse monoclonal IgG1 κ, cited in 12 publications, provided at 200 µg/ml
- epitope corresponding to amino acids 777-790 mapping at the C-terminus of Trk of human origin
- recommended for detection of Trk A, Trk B and Trk C of mouse, rat and human origin by WB, IP, IF and IHC(P)
- available conjugated to agarose for IP
- See Trk (B-3): sc-7268 for Trk antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Trk Antibody (MCTrks) for WB and IHC(P) applications. These reagents are now offered in bundles with Trk Antibody (MCTrks) (see ordering information below).
Trk Antibody (MCTrks) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize the Trk family of receptors, including Trk A (NTRK1), Trk B (NTRK2), and Trk C (NTRK3), across mouse, rat, and human species. Trk monoclonal antibody (MCTrks) specifically binds to an epitope corresponding to amino acids 777-790 at the C-terminus of the human Trk proteins, making anti-Trk antibody (MCTrks) ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). The Trk receptors are integral membrane proteins located on the cell surface, where they function as essential tyrosine kinase receptors for neurotrophic factors like nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). These receptors play a pivotal role in the development, maintenance, and function of both the central and peripheral nervous systems by regulating neuronal survival, differentiation, and synaptic plasticity. The strategic localization of Trk receptors on the cell membrane allows them to effectively receive and transduce extracellular signals, which is crucial for cellular communication and response to environmental stimuli. Trk (MCTrks) antibody enables researchers to examine the spatial distribution and expression levels of Trk proteins within various cellular environments, thereby enhancing the understanding of neurodevelopmental processes and neurological disorders. Whether utilized to investigate receptor localization in tissue samples or to explore the mechanisms of Trk-mediated signal transduction, Trk monoclonal antibody (MCTrks) is recommended for use in neuroscience research and the development of therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trk Antibody (MCTrks) | sc-414 | 200 µg/ml | $322.00 | |||
Trk Antibody (MCTrks): m-IgG Fc BP-HRP Bundle | sc-536538 | 200 µg Ab; 10 µg BP | $361.00 | |||
Trk Antibody (MCTrks): m-IgGκ BP-HRP Bundle | sc-533689 | 200 µg Ab; 40 µg BP | $361.00 | |||
Trk Antibody (MCTrks): m-IgG1 BP-HRP Bundle | sc-544663 | 200 µg Ab; 20 µg BP | $361.00 | |||
Trk Antibody (MCTrks) AC | sc-414 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Trk (MCTrks) Neutralizing Peptide | sc-414 P | 100 µg/0.5 ml | $69.00 |