Date published: 2025-10-15

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Trk Inhibitors

Santa Cruz Biotechnology now offers a broad range of Trk Inhibitors for use in various applications. Trk Inhibitors, or tropomyosin receptor kinase inhibitors, are a class of compounds that target the Trk family of tyrosine kinases, which includes TrkA, TrkB, and TrkC. These kinases are primarily involved in the regulation of neuronal development and function, making them critical in neurobiology and neuropharmacology research. In scientific studies, Trk Inhibitors are essential tools for dissecting the roles of neurotrophin signaling pathways in various biological processes, including cell differentiation, survival, and synaptic plasticity. Researchers utilize these inhibitors to explore the mechanisms of neurodegenerative diseases, neural development, and the effects of neurotrophin signaling on neural stem cells. Furthermore, Trk Inhibitors are valuable in the study of oncogenic pathways, as aberrations in Trk signaling are implicated in certain types of cancer. By inhibiting these kinases, scientists can gain insights into the molecular underpinnings of tumor growth and progression, providing a basis for further research into targeted therapies. View detailed information on our available Trk Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin functions as a modulator of the Trk receptor family, exhibiting distinct interactions that stabilize receptor dimerization. This compound influences the allosteric dynamics of Trk receptors, facilitating enhanced binding to neurotrophic factors. By altering the kinetics of receptor activation, Quercetin promotes specific phosphorylation events, thereby fine-tuning downstream signaling cascades that are crucial for cellular responses and neuroplasticity.

GW441756 hydrochloride

504433-24-3 (free base)sc-215121
5 mg
$140.00
(0)

GW441756 hydrochloride acts as a selective Trk receptor modulator, engaging in unique molecular interactions that promote receptor conformational changes. Its binding affinity influences the receptor's oligomerization state, enhancing the specificity of neurotrophic factor interactions. This compound also impacts the kinetics of receptor internalization and recycling, thereby modulating the duration and intensity of signaling pathways critical for neuronal development and function.