transgelin-2 Antibody (G-5): sc-166697

transgelin-2 Antibody (G-5) is a mouse monoclonal IgG2b antibody that detects transgelin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Transgelin-2, also known as SM22α homolog, is a crucial protein expressed predominantly in smooth muscle cells and peritoneal B-1 cells, playing a significant role in smooth muscle contraction and cellular signaling regulation. The human transgelin-2 gene, designated TAGLN2, is located on chromosome 1q23.1-q25 and encodes a 199 amino acid protein featuring a calponin-like repeat and a calponin-homology domain, essential for actin filament interaction. This interaction is vital as transgelin-2 binds to actin at a ratio of 1:6 actin monomers, leading to actin fiber gelling within minutes, influencing cytoskeletal dynamics and cellular morphology. Notably, transgelin-2 expression is downregulated in various transformed cell lines, suggesting reduced levels may serve as an early biomarker for cellular transformation and tumorigenesis. Transgelin-2′s ability to modulate actin dynamics underscores its importance in maintaining smooth muscle function and potential implications in vascular diseases and cancer progression.

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transgelin-2 Antibody (G-5) References:

1. Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma.  |  Sun, Y., et al. 2017. Oncotarget. 8: 49592-49604. PMID: 28521289
2. Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.  |  Yin, LM., et al. 2018. Sci Transl Med. 10: PMID: 29437149
3. Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer.  |  Sun, Y., et al. 2018. J Exp Clin Cancer Res. 37: 166. PMID: 30041673
4. Transgelin-2 expression in breast cancer and its relationships with clinicopathological features and patient outcome.  |  Hao, R., et al. 2019. Breast Cancer. 26: 776-783. PMID: 31144206
5. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.  |  Kim, HR., et al. 2021. J Hematol Oncol. 14: 43. PMID: 33731208
6. Mechanisms of Transgelin-2 in Tumorigenesis.  |  Zeng, C. and Zhang, H. 2021. Discov Med. 32: 23-28. PMID: 35219353
7. Transgelin-2 as an Early Detection for Diabetic Nephropathy Through Inflammation, Periostin and E-cadherin by STAT3 Signaling Through ANXA2.  |  Duan, X., et al. 2023. Clin Lab. 69: PMID: 37560863
8. Discovery of zolinium TSG1180 as a novel agonist of transgelin-2 for treating asthma.  |  Yuan, HK., et al. 2023. Biomed Pharmacother. 167: 115556. PMID: 37778269
9. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.  |  Zhang, X., et al. 2023. Nat Commun. 14: 6670. PMID: 37865646
10. Transgelin 2 guards T cell lipid metabolism and antitumour function.  |  Hwang, SM., et al. 2024. Nature. 635: 1010-1018. PMID: 39443795

The preferred transgelin-2 antibody is transgelin-2 Antibody (C-12): sc-373928.