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TRα1/β1 Antibody (C1) - Western Blotting - Image 55103
TRα1/β1 Antibody (C1): sc-739. Western blot analysis of TRα expression in non-transfected: sc-117752 (A) and human TRα transfected: sc-170626 (B) 293T whole cell lysates.
TRα1/β1 Antibody (C1) - Western Blotting - Image 55103
TRα1/β1 Antibody (C1): sc-739. Western blot analysis of TRα expression in non-transfected: sc-117752 (A) and human TRα transfected: sc-170626 (B) 293T whole cell lysates.
TRα1/β1 Antibody (C1) - Western Blotting - Image 1667
Western blot analysis of TRβ1 expression in ZL (293 cells stably expressing TRβ1) whole cell lysate. Antibodies tested include TRα1/β1 Antibody (C1): sc-739 (A) and TRα1/β1 (C4): sc-740 (B). Kindly provided by Sheue-Yann Cheng at the National Institutes of Health.
TRα1/β1 Antibody (C1): sc-739. Western blot analysis of TRα expression in non-transfected: sc-117752 (A) and human TRα transfected: sc-170626 (B) 293T whole cell lysates.

TRα1/β1 Antibody (C1): sc-739

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Datasheets
  • TRα1/β1 Antibody (C1) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
  • epitope mapping within the ligand binding domain of TRα1 of human origin
  • recommended for detection of TRα1 and TRβ1 of mouse, rat and human origin by WB, IP and IF
  • TransCruz reagent for Gel Supershift and ChIP applications (sc-739 X, 200 µg/0.1 ml)
  • See TRβ1 (J51): sc-737 for TRα1/β1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRα1/β1 Antibody (C1) for WB applications. These reagents are now offered in bundles with TRα1/β1 Antibody (C1) (see ordering information below).
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Additional Thyroid Receptor Antibodies including TR α 2 and TR β 1

TRα1/β1 Antibody (C1) is a mouse monoclonal IgG1 antibody that detects TRα1/β1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TRα1/β1 plays a crucial role in the regulation of metabolic and developmental processes as a ligand-dependent transcription factor that binds to thyroid hormone response elements (TREs). TRα1/β1 (C1) monoclonal antibody recognizes TRα1, which can localize to both the nucleus and the cytoplasm, and is the only thyroid hormone receptor imported into the mitochondrial matrix, highlighting its importance in cellular metabolism and energy regulation. This localization suggests that TRα1 may have distinct roles in mitochondrial function and gene expression, potentially influencing metabolic pathways and energy homeostasis. TRs interact with retinoid X receptors (RXRs) to form heterodimers, which further modulate transcriptional activity, underscoring the complexity of thyroid hormone signaling. TRα1/β1 (C1) monoclonal antibody serves as an essential tool for researchers studying the intricate mechanisms of thyroid hormone action and its implications in various physiological and pathological conditions.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

TRα1/β1 Antibody (C1) References:

  1. Clinical phenotype and mutant TRα1.  |  van Mullem, A., et al. 2012. N Engl J Med. 366: 1451-3. PMID: 22494134
  2. T3 enhances thyroid cancer cell proliferation through TRβ1/Oct-1-mediated cyclin D1 activation.  |  Perri, A., et al. 2014. Mol Cell Endocrinol. 382: 205-217. PMID: 24121026
  3. The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.  |  Hahm, JB., et al. 2014. Mol Cell Endocrinol. 383: 80-95. PMID: 24325866
  4. The emerging role of TRα1 in cardiac repair: potential therapeutic implications.  |  Pantos, C. and Mourouzis, I. 2014. Oxid Med Cell Longev. 2014: 481482. PMID: 24683435
  5. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.  |  Astapova, I., et al. 2014. J Clin Invest. 124: 1976-86. PMID: 24713658
  6. Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway.  |  Godart, M., et al. 2021. Development. 148: PMID: 33757992
  7. Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer.  |  Sirakov, M., et al. 2021. Front Endocrinol (Lausanne). 12: 725708. PMID: 34956074
  8. Ontogeny of TRα1 expression in the mouse testis and epididymis during postnatal development.  |  Sarkar, D., et al. 2022. Andrologia. 54: e14507. PMID: 35753757
  9. Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions.  |  Giolito, MV., et al. 2022. Mol Oncol. 16: 3975-3993. PMID: 36217307
  10. Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues.  |  Ng, L., et al. 2023. Front Endocrinol (Lausanne). 14: 1174600. PMID: 37033230

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TRα1/β1 Antibody (C1)

sc-739
200 µg/ml
$322.00

TRα1/β1 Antibody (C1): m-IgG Fc BP-HRP Bundle

sc-536542
200 µg Ab; 10 µg BP
$361.00

TRα1/β1 Antibody (C1): m-IgGκ BP-HRP Bundle

sc-533693
200 µg Ab; 40 µg BP
$361.00

TRα1/β1 Antibody (C1): m-IgG1 BP-HRP Bundle

sc-544665
200 µg Ab; 20 µg BP
$361.00

TRα1/β1 Antibody (C1) X

sc-739 X
200 µg/0.1 ml
$322.00

When should the TransCruz reagent sc-739 X be used instead of the standard form sc-739?

Asked by: AbPolly
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from specific signalGives good and specific signal for both unmodified and mono-ubiquitinated TR alpha 1/ beta 1 on WB (use no less than 1:200).
Date published: 2017-04-23
Rated 5 out of 5 by from Gave great signal in our WB and we used itGave great signal in our WB and we used it at a 1:400 dilution.
Date published: 2015-09-17
Rated 4 out of 5 by from Strong band in WB in bovineStrong band in WB in bovine, human, mouse, African green monkey BAEC, HUVEC, HeLa, NIH3T3, MEF, COS7. -SCBT Publication Review
Date published: 2015-07-14
Rated 4 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-06-23
Rated 4 out of 5 by from Good specificity in WB in ZL 293 cellsGood specificity in WB in ZL 293 cells. -SCBT QC
Date published: 2015-05-04
Rated 4 out of 5 by from Good publishable data in WBGood publishable data in WB, IP and IF in human and monkey Hek293, Hela, Cos-7 cells. -SCBT Publication Review
Date published: 2013-07-13
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TRα1/β1 Antibody (C1) is rated 4.3 out of 5 by 6.
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