Anti-TRα1/β1 Antibody (C4) is a mouse monoclonal IgG1TRα1/β1 antibody provided at 200 µg/ml
epitope mapping within the C-terminus of TRα1 of human origin
TR alpha 1/ beta 1 Antibody (C4) is recommended for detection of TRα1 and TRβ1 of human origin by WB, IP and IF
Anti-TR alpha 1/ beta 1 Antibody (C4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for Gel Supershift and ChIP applications (sc-740 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TRα1/β1 (C4): sc-740.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TRα1/β1 Antibody (C4) is a high quality monoclonal TR alpha 1/ beta 1 antibody (also designated TRα1/β1 antibody) suitable for the detection of the TR alpha 1/ beta 1 protein of human origin. TRα1/β1 Antibody (C4) is available as both the non-conjugated anti-TR alpha 1/ beta 1 antibody form, as well as multiple conjugated forms of anti-TR alpha 1/ beta 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate and control many metabolic and developmental processes. There are two genes encoding TRs identified to date, TRα and TRβ. TRs bind to thyroid hormone response elements (TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3′-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRα, RXRβ and RXRγ). The TRα isoform, TRα1, can display both a nuclear and undefined cytoplasmic location, and is the only TR that is imported into the mitochondrial matrix. The TRβ isoform TRβ1 forms a complex with the PI 3-kinase p85α subunit and plays an important role in the T3-induced activation of Akt in pancreatic β cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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