TRAF2 Antibody (D-3): sc-136997

TRAF2 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects TRAF2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) receptor signaling, particularly through interaction with TNF receptor 2 (TNF-R2), which is essential for regulating immune responses and inflammation. TRAF2 is primarily located in the cytoplasm, where TRAF2 forms heterodimeric complexes with TRAF1 and other signaling molecules, facilitating signal transmission from TNF receptors to downstream effectors. This localization allows TRAF2 to effectively participate in assembling signaling complexes that activate various transcription factors, ultimately influencing cell survival, proliferation, and apoptosis. Understanding TRAF2 function and cellular dynamics is important for elucidating TRAF2′s role in pathological conditions such as autoimmune diseases and cancer, where dysregulation of TNF signaling can lead to detrimental effects on tissue homeostasis. Anti-TRAF2 antibody (D-3) is an invaluable tool for researchers exploring the complexities of TNF receptor-mediated signaling pathways and their implications in health and disease.

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TRAF2 Antibody (D-3) References:

1. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.  |  Wang, B., et al. 2017. Nature. 545: 365-369. PMID: 28489822
2. LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis.  |  Wu, G., et al. 2021. Nat Cancer. 2: 1170-1184. PMID: 35122056
3. TRAF2 Mediates Physiological Mitophagy.  |  Sadoshima, J. 2022. JACC Basic Transl Sci. 7: 244-246. PMID: 35411322
4. TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2.  |  Qian, Y., et al. 2022. Signal Transduct Target Ther. 7: 148. PMID: 35513381
5. TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer.  |  Siegmund, D., et al. 2022. Cancers (Basel). 14: PMID: 36011046
6. TRAF2 regulates the protein stability of HIPK2.  |  Lee, I., et al. 2022. Biochem Biophys Res Commun. 627: 97-102. PMID: 36030658
7. TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD+/SIRT3/SOD2 axis.  |  Yao, J., et al. 2024. Free Radic Biol Med. 211: 47-62. PMID: 38043870
8. Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.  |  Deen, AJ., et al. 2024. Redox Biol. 69: 103031. PMID: 38184997
9. Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.  |  Jaeger-Ruckstuhl, CA., et al. 2024. Immunity. 57: 287-302.e12. PMID: 38354704
10. TRAF2 decrease promotes the TGF-β-mTORC1 signal in MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.  |  Li, Z., et al. 2024. FASEB J. 38: e23491. PMID: 38363556

The preferred TRAF2 antibody is TRAF2 Antibody (H-10): sc-7346.