TRAF2 Antibody (D-3): sc-136997

TRAF2 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects TRAF2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) receptor signaling, particularly through interaction with TNF receptor 2 (TNF-R2), which is essential for regulating immune responses and inflammation. TRAF2 is primarily located in the cytoplasm, where TRAF2 forms heterodimeric complexes with TRAF1 and other signaling molecules, facilitating signal transmission from TNF receptors to downstream effectors. This localization allows TRAF2 to effectively participate in assembling signaling complexes that activate various transcription factors, ultimately influencing cell survival, proliferation, and apoptosis. Understanding TRAF2 function and cellular dynamics is important for elucidating TRAF2′s role in pathological conditions such as autoimmune diseases and cancer, where dysregulation of TNF signaling can lead to detrimental effects on tissue homeostasis. Anti-TRAF2 antibody (D-3) is an invaluable tool for researchers exploring the complexities of TNF receptor-mediated signaling pathways and their implications in health and disease.

The preferred TRAF2 antibody is TRAF2 Antibody (H-10): sc-7346.