TRAF2 Antibody (H-10): sc-7346
- TRAF2 Antibody (H-10) is a mouse monoclonal IgG1 λ, cited in 36 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 478-497 at the C-terminus of TRAF2 of mouse origin
- Anti-TRAF2 Antibody (H-10) is recommended for detection of TRAF2 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA; also reactive with additional species, including and canine and bovine
- Anti-TRAF2 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for TRAF2 Antibody (H-10) for WB and IHC(P) applications. This reagent is now offered in a bundle with TRAF2 Antibody (H-10) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
TRAF2 Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects TRAF2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). TRAF2 Antibody (H-10) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) signaling, primarily through interaction with TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF receptor 2 (TNF-R2). TRAF2 is located in the cytoplasm, where TRAF2 forms heterodimeric complexes with TRAF1 and associates with the cytoplasmic domains of TNF receptors, facilitating downstream signaling pathways vital for immune responses and inflammation. TRAF2 functioning is essential for the regulation of cell survival, proliferation, and apoptosis, making TRAF2 a significant player in various pathological conditions, including cancer and autoimmune diseases. Understanding TRAF2 dynamics and interactions can provide valuable insights into therapeutic strategies targeting TNF receptor-mediated signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF2 Antibody (H-10) References:
- Two TNF receptors. | Tartaglia, LA. and Goeddel, DV. 1992. Immunol Today. 13: 151-3. PMID: 1322675
- Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. | Hu, M., et al. 2017. Mol Cell. 66: 141-153.e6. PMID: 28388439
- TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. | Li, J., et al. 2019. Cell Death Dis. 10: 328. PMID: 30988281
- Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. | Dhingra, R., et al. 2022. Circulation. 146: 934-954. PMID: 35983756
- The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. | Liang, X., et al. 2023. Cell Death Differ. 30: 1550-1562. PMID: 37081115
- TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma. | Xu, Y., et al. 2023. J Exp Clin Cancer Res. 42: 159. PMID: 37415241
- A novel RING finger protein interacts with the cytoplasmic domain of CD40. | Hu, HM., et al. 1994. J Biol Chem. 269: 30069-72. PMID: 7527023
- Involvement of CRAF1, a relative of TRAF, in CD40 signaling. | Cheng, G., et al. 1995. Science. 267: 1494-8. PMID: 7533327
- The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. | Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
- The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. | Mosialos, G., et al. 1995. Cell. 80: 389-99. PMID: 7859281
- A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. | Rothe, M., et al. 1994. Cell. 78: 681-92. PMID: 8069916
- The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. | Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF2 Antibody (H-10) | sc-7346 | 200 µg/ml | $316.00 | |||
TRAF2 Antibody (H-10): m-IgGλ BP-HRP Bundle | sc-520497 | 200 µg Ab, 40 µg BP | $354.00 | |||
TRAF2 Antibody (H-10) AC | sc-7346 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TRAF2 Antibody (H-10) HRP | sc-7346 HRP | 200 µg/ml | $316.00 | |||
TRAF2 Antibody (H-10) FITC | sc-7346 FITC | 200 µg/ml | $330.00 | |||
TRAF2 Antibody (H-10) PE | sc-7346 PE | 200 µg/ml | $343.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 488 | sc-7346 AF488 | 200 µg/ml | $357.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 546 | sc-7346 AF546 | 200 µg/ml | $357.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 594 | sc-7346 AF594 | 200 µg/ml | $357.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 647 | sc-7346 AF647 | 200 µg/ml | $357.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 680 | sc-7346 AF680 | 200 µg/ml | $357.00 | |||
TRAF2 Antibody (H-10) Alexa Fluor® 790 | sc-7346 AF790 | 200 µg/ml | $357.00 | |||
TRAF2 (H-10) Neutralizing Peptide | sc-7346 P | 100 µg/0.5 ml | $68.00 |