TRAF1 Antibody (E-12): sc-271683
- TRAF1 Antibody (E-12) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of TRAF1 of mouse origin
- recommended for detection of TRAF1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See TRAF1 (H-3): sc-6253 for TRAF1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRAF1 Antibody (E-12) for WB applications. These reagents are now offered in bundles with TRAF1 Antibody (E-12) (see ordering information below).
TRAF1 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects TRAF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF1 plays a crucial role in the regulation of immune responses and cell survival by mediating signaling pathways initiated by various receptors, including the tumor necrosis factor receptor (TNF-R). TRAF1 is primarily located in the cytoplasm, where TRAF1 forms complexes with other signaling molecules, such as TRAF2, to propagate downstream signaling cascades that influence cell proliferation and apoptosis. The proper functioning of TRAF1 is vital for maintaining immune homeostasis, and dysregulation of TRAF1 activity has been implicated in various inflammatory diseases and cancers. Anti-TRAF1 antibody (E-12) is an essential tool for researchers aiming to explore the intricate mechanisms of immune signaling and the potential therapeutic targets within these pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF1 Antibody (E-12) References:
- Role of 4-1BBL and TRAF1 in the CD8 T cell response to influenza virus and HIV. | Watts, TH., et al. 2011. Adv Exp Med Biol. 691: 177-86. PMID: 21153322
- TRAF1 is a key mediator for hepatic ischemia/reperfusion injury. | Zhang, XF., et al. 2014. Cell Death Dis. 5: e1467. PMID: 25321474
- TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. | Greenfeld, H., et al. 2015. PLoS Pathog. 11: e1004890. PMID: 25996949
- Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. | Xiang, M., et al. 2016. J Hepatol. 64: 1365-77. PMID: 26860405
- TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation. | Bin, W., et al. 2019. Biochem Biophys Res Commun. 511: 49-56. PMID: 30760405
- TRAF1 Exacerbates Myocardial Ischemia Reperfusion Injury via ASK1-JNK/p38 Signaling. | Xu, W., et al. 2019. J Am Heart Assoc. 8: e012575. PMID: 31650881
- Comparison of Target Recognition by TRAF1 and TRAF2. | Kim, CM. and Park, HH. 2020. Int J Mol Sci. 21: PMID: 32326186
- The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia. | Edilova, MI., et al. 2021. Oncoimmunology. 10: 1943234. PMID: 34589290
- CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway. | Cheng, T., et al. 2022. J Bone Miner Metab. 40: 819-828. PMID: 35960381
- TRAF1 improves cisplatin-induced acute kidney injury via inhibition of inflammation and metabolic disorders. | Zhang, X., et al. 2023. Biochim Biophys Acta Gen Subj. 1867: 130423. PMID: 37419425
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF1 Antibody (E-12) | sc-271683 | 200 µg/ml | $322.00 | |||
TRAF1 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-537680 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRAF1 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-535023 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRAF1 Antibody (E-12): m-IgG1 BP-HRP Bundle | sc-545302 | 200 µg Ab; 20 µg BP | $361.00 | |||
TRAF1 (E-12) Neutralizing Peptide | sc-271683 P | 100 µg/0.5 ml | $69.00 |