TRAF1 Inhibitors
TRAF1 inhibitors represent a class of chemical compounds designed to target and modulate the activity of the TNF receptor-associated factor 1 (TRAF1) protein. TRAF1 is a crucial component of the tumor necrosis factor (TNF) signaling pathway, a key pathway in the immune system involved in inflammation and cell survival. This protein plays a pivotal role in regulating the cellular response to various stressors and immune challenges. TRAF1 inhibitors are designed to interact with TRAF1, either directly or indirectly, with the aim of disrupting its normal function. By doing so, they can influence downstream signaling events in the TNF pathway, ultimately affecting the immune and inflammatory responses within the body.
Chemically, TRAF1 inhibitors can take various forms, including small molecules or peptides, which are meticulously designed to interact with specific regions or domains of the TRAF1 protein. These inhibitors work by interfering with the protein-protein interactions that TRAF1 engages in to initiate downstream signaling cascades. By blocking or modulating these interactions, TRAF1 inhibitors can exert control over the activation of various immune responses.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
While primarily known as a Bruton's tyrosine kinase (BTK) inhibitor, CC-292 also affects TRAF1 signaling pathways, making it relevant in conditions like rheumatoid arthritis. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Derived from the Chinese herb Tripterygium wilfordii, triptolide has demonstrated anti-inflammatory properties by inhibiting TRAF1 and other pro-inflammatory molecules. | ||||||
Cytosporone B | 321661-62-5 | sc-252653 | 5 mg | $146.00 | 7 | |
A natural compound found in fungi, cytosporone B has shown potential as a TRAF1 inhibitor, modulating immune responses and inflammation. | ||||||
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $361.00 | 1 | |
Found in hops, xanthohumol exhibits anti-inflammatory properties by inhibiting TRAF1 signaling pathways, making it a potential therapeutic option for autoimmune diseases. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
The active compound in turmeric, curcumin, has anti-inflammatory effects and can inhibit TRAF1 expression, potentially reducing inflammation in various conditions. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Derived from the Ayurvedic herb Ashwagandha, withaferin A can downregulate TRAF1 expression, making it a candidate for anti-inflammatory therapies. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Isolated from the Andrographis paniculata plant, andrographolide inhibits TRAF1 and other pro-inflammatory molecules, showing promise in various inflammatory disorders. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
A natural compound from the Chinese Thunder of God Vine, celastrol has been studied for its anti-inflammatory properties, including its ability to inhibit TRAF1-mediated signaling pathways. | ||||||