Molecular structure of Cytosporone B, CAS Number: 321661-62-5
Cytosporone B (CAS 321661-62-5)
See product citations (7)
Alternate Names:
3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester, Csn-B; 3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester, Csn-B
Application:
Cytosporone B is a naturally occuring agonist of the Nur77 receptor
CAS Number:
321661-62-5
Purity:
≥98%
Molecular Weight:
322.40
Molecular Formula:
C18H26O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytosporone B is the first occurring agonist for nuclear orphan receptor Nur77 is Cytosporone B. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.
Cytosporone B (CAS 321661-62-5) References
- Cytosporone B is an agonist for nuclear orphan receptor Nur77. | Zhan, Y., et al. 2008. Nat Chem Biol. 4: 548-56. PMID: 18690216
- Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. | Li, J., et al. 2013. Antimicrob Agents Chemother. 57: 2191-8. PMID: 23459474
- Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability. | Xia, Z., et al. 2013. Medchemcomm. 4: 332-339. PMID: 24795803
- Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice. | Egarnes, B., et al. 2017. PLoS One. 12: e0186639. PMID: 29053748
- Hypoxia/reperfusion predisposes to atherosclerosis. | Finsterwalder, R., et al. 2018. PLoS One. 13: e0205067. PMID: 30289932
- The effects of cytosporone-B, a novel antifibrotic agent, on vocal fold fibroblasts. | Hiwatashi, N., et al. 2018. Laryngoscope. 128: E425-E428. PMID: 30325029
- Cytosporone B as a Biological Preservative: Purification, Fungicidal Activity and Mechanism of Action against Geotrichum citri-aurantii. | Yin, C., et al. 2019. Biomolecules. 9: PMID: 30934892
- The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo. | Ismaiel, M., et al. 2021. Biochem Biophys Res Commun. 554: 179-185. PMID: 33798945
- Orphan nuclear receptor 4A1 (NR4A1) and novel ligands. | Safe, S., et al. 2021. Essays Biochem. 65: 877-886. PMID: 34096590
- Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts. | Pulakazhi Venu, VK., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321: G280-G297. PMID: 34288735
- Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells. | Ding, X., et al. 2022. Int Immunopharmacol. 104: 108521. PMID: 35026656
- NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis. | Yu, HZ., et al. 2022. Neural Regen Res. 17: 2765-2770. PMID: 35662227
- Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. | Li, Q., et al. 2022. Front Immunol. 13: 930397. PMID: 35757735
- The Nurr7 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages. | Patiño-Martínez, E., et al. 2022. Immunobiology. 227: 152299. PMID: 36370518
- Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. | Amititeloaie, C., et al. 2023. Rom J Morphol Embryol. 64: 35-40. PMID: 37128789
Inhibitor of:
Dyrk1B, EG236749, Filamin 1, GAP-43, GFAP, Laminin α-3, Perforin 1, Phakinin, PSTPIP2, SMC1α, Smooth Muscle Actin, THSD4, TRAF1, Vmn1r12, and Zyxin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytosporone B, 5 mg | sc-252653 | 5 mg | $143.00 |