TORC2 Antibody (D-2): sc-390765

TORC2 Antibody (D-2) is a mouse monoclonal IgG2b antibody that detects TORC2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TORC2, or transducer of regulated cAMP response element-binding protein 2, plays a crucial role in the regulation of gene expression by acting as a coactivator for the cAMP-responsive element-binding protein (CREB). TORC2 is primarily located in the nucleus, where TORC2 is involved in the transcriptional activation of genes in response to hormonal signals, particularly those mediated by cAMP. Nuclear localization of TORC2 is vital for function, as this allows for precise regulation of gene expression in response to cellular signals, thereby influencing various physiological processes such as metabolism, cell growth, and differentiation. TORC2 undergoes phosphorylation, which modulates activity and interaction with other proteins, further emphasizing TORC2′s importance in cellular signaling pathways. Anti-TORC2 antibody (D-2) is an essential tool for researchers studying the intricate mechanisms of gene regulation and the role of TORC proteins in health and disease.

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TORC2 Antibody (D-2) References:

1. TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.  |  Siu, YT., et al. 2006. J Virol. 80: 7052-9. PMID: 16809310
2. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.  |  Tabuchi, M., et al. 2006. Mol Cell Biol. 26: 5861-75. PMID: 16847337
3. TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.  |  Murata, T., et al. 2009. J Biol Chem. 284: 8033-41. PMID: 19164291
4. Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells.  |  Yuan, J., et al. 2009. J Virol. 83: 6391-403. PMID: 19369332
5. The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription.  |  Kim, YM., et al. 2010. Oncogene. 29: 2142-52. PMID: 20101207
6. A Ras signaling complex controls the Rasc-TORC2 pathway and directed cell migration.  |  Charest, PG., et al. 2010. Dev Cell. 18: 737-49. PMID: 20493808
7. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.  |  Kim, SJ., et al. 2010. J Lipid Res. 51: 3145-57. PMID: 20693566
8. Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.  |  Rahmani, M., et al. 2015. Haematologica. 100: 1553-63. PMID: 26452980
9. Chemical probing of HER2-amplified cancer cells identifies TORC2 as a particularly effective secondary target for combination with lapatinib.  |  Amin, DN., et al. 2015. Oncotarget. 6: 41123-33. PMID: 26516700
10. Tumor-suppressor Fbxw7 targets SIK2 for degradation to interfere with TORC2-AKT signaling in pancreatic cancer.  |  Zhang, MX., et al. 2020. Cell Biol Int. 44: 1900-1910. PMID: 32437091

The preferred TORC2 antibody is TORC2 Antibody (F-4): sc-271912.