TNAP Antibody (3H414): sc-73525

TNAP Antibody (3H414) is a mouse monoclonal IgG1 antibody that detects tissue non-specific alkaline phosphatase (TNAP) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TNAP is a crucial enzyme that plays a significant role in bone mineralization, functioning alongside plasma cell membrane glycoprotein-1 to facilitate the deposition of minerals in the bone matrix. This process is vital for maintaining bone integrity and strength, and any disruption can lead to serious conditions. Notably, mutations or deficiencies in TNAP are directly linked to hypophosphatasia, a rare genetic disorder characterized by impaired bone mineralization, resulting in skeletal deformities and increased fracture risk. The human gene encoding TNAP is located on chromosome 1p36.12, and widespread expression in tissues such as the liver, kidney, and bone underscores TNAP′s importance in various physiological processes. Anti-TNAP antibody (3H414) is an essential tool for researchers studying bone metabolism and related disorders, providing reliable detection and analysis of this critical protein.

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TNAP Antibody (3H414) References:

1. Association of a TNAP haplotype with ankylosing spondylitis.  |  Tsui, HW., et al. 2007. Arthritis Rheum. 56: 234-43. PMID: 17195227
2. Mutations of the tissue non-specific alkaline phosphatase gene (TNAP) causing a non-lethal case of perinatal hypophosphatasia.  |  Peach, CA., et al. 2007. Rheumatology (Oxford). 46: 1037-40. PMID: 17409132
3. Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).  |  Sidique, S., et al. 2009. Bioorg Med Chem Lett. 19: 222-5. PMID: 19038545
4. Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription.  |  Kim, HN., et al. 2011. J Bone Miner Res. 26: 2161-73. PMID: 21590736
5. Novel heterozygous tissue-nonspecific alkaline phosphatase (TNAP) gene mutations causing lethal perinatal hypophosphatasia.  |  Chang, KC., et al. 2012. J Bone Miner Metab. 30: 109-13. PMID: 21638016
6. A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples.  |  Sergienko, EA., et al. 2013. Methods Mol Biol. 1053: 103-13. PMID: 23860649
7. Genetically Modified Mice for Studying TNAP Function.  |  Narisawa, S. 2015. Subcell Biochem. 76: 45-57. PMID: 26219706
8. TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body.  |  Goettsch, C., et al. 2022. Cardiovasc Res. 118: 84-96. PMID: 33070177
9. TNAP: A New Multitask Enzyme in Energy Metabolism.  |  Briolay, A., et al. 2021. Int J Mol Sci. 22: PMID: 34638808
10. Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors.  |  Haider, MB., et al. 2024. Int J Biol Macromol. 283: 137699. PMID: 39551301

The preferred TNAP antibody is TNAP Antibody (TRA-2-39): sc-21708.