Date published: 2025-10-15

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TNAP Inhibitors

TNAP inhibitors constitute a diverse group of compounds that modulate the activity of tissue-nonspecific alkaline phosphatase (TNAP), either directly or indirectly. Levamisole, an alkaline phosphatase inhibitor, acts indirectly by interfering with the proper folding and maturation of TNAP, resulting in reduced enzyme activity. Similarly, lansoprazole, a proton pump inhibitor, indirectly impacts TNAP by altering intracellular pH, affecting the enzyme's conformation and function. Sodium orthovanadate, a phosphatase inhibitor, indirectly influences TNAP by modulating cellular phosphate levels through the inhibition of various phosphatases. Pyrophosphate, a substrate analog, competes with TNAP substrates, acting as a competitive inhibitor and reducing enzyme activity. Beta-glycerophosphate, another TNAP substrate analog, acts as a substrate mimic, enhancing TNAP activity by providing an alternative substrate.Ibandronate, a bisphosphonate, indirectly affects TNAP activity by influencing the availability of phosphate ions in the extracellular matrix during bone metabolism. Zinc chloride, a TNAP inhibitor, has been implicated in modulating TNAP activity, although the exact mechanism remains unclear. 5'-Methylthioadenosine, an endogenous metabolite, may influence TNAP activity by affecting cellular signaling pathways or metabolic processes. Menadione, a vitamin K analog, may modulate TNAP activity, although the specific mechanism is not well-defined. Phosphonoformic acid and zinc acetate are reported TNAP inhibitors, affecting enzyme activity by competing with substrates.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Homoarginine-d4 Dihydrochloride

1332075-41-8sc-280882
sc-280882-CW
sc-280882A
1 mg
1 mg
10 mg
$331.00
$444.00
$2341.00
(0)

L-Homoarginine-d4 Dihydrochloride is a stable isotopically labeled compound that exhibits unique interactions with nitric oxide synthase, influencing enzymatic activity and metabolic pathways. Its deuterated form enhances the precision of kinetic studies, allowing for detailed analysis of reaction mechanisms. The compound's solubility and stability in various conditions facilitate its use in biochemical assays, providing insights into arginine metabolism and related physiological processes.

Levamisole Hydrochloride

16595-80-5sc-205730
sc-205730A
5 g
10 g
$42.00
$67.00
18
(1)

Alkaline phosphatase inhibitor indirectly impacting TNAP. Levamisole interferes with the proper folding and maturation of TNAP, leading to reduced enzyme activity.

Lansoprazole

103577-45-3sc-203101
sc-203101A
500 mg
1 g
$58.00
$173.00
6
(0)

Proton pump inhibitor indirectly affecting TNAP by altering intracellular pH. Lansoprazole inhibits the H+/K+ ATPase in gastric parietal cells, leading to increased acidity in the endoplasmic reticulum and potential misfolding of TNAP.

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$45.00
$56.00
$183.00
142
(4)

Phosphatase inhibitor indirectly influencing TNAP. Sodium orthovanadate inhibits various phosphatases, potentially impacting TNAP activity through modulation of cellular phosphate levels.

Sodium pyrophosphate dibasic

7758-16-9sc-251047
sc-251047A
sc-251047B
100 g
200 g
1 kg
$83.00
$114.00
$434.00
1
(1)

Substrate analog indirectly affecting TNAP. Pyrophosphate competes with TNAP substrates, acting as a competitive inhibitor and potentially reducing enzyme activity.

β-Glycerophosphate disodium salt

819-83-0sc-220452
sc-220452A
sc-220452B
sc-220452C
sc-220452D
sc-220452E
25 g
100 g
500 g
1 kg
3 kg
6 kg
$62.00
$117.00
$433.00
$724.00
$2050.00
$3580.00
43
(1)

TNAP substrate analog influencing TNAP activity. Beta-Glycerophosphate acts as a substrate mimic, potentially enhancing TNAP activity by providing an alternative substrate for the enzyme.

Sodium Fluoride

7681-49-4sc-24988A
sc-24988
sc-24988B
5 g
100 g
500 g
$39.00
$45.00
$98.00
26
(4)

Phosphatase inhibitor indirectly influencing TNAP. Sodium fluoride inhibits various phosphatases, potentially impacting TNAP activity through modulation of cellular phosphate levels.

Ibandronate Sodium Monohydrate

138926-19-9sc-218589
100 mg
$290.00
(0)

Bisphosphonate indirectly affecting TNAP. Ibandronate, a bisphosphonate, is involved in bone metabolism and may indirectly impact TNAP activity by influencing the availability of phosphate ions in the extracellular matrix.

5′-Deoxy-5′-methylthioadenosine

2457-80-9sc-202427
50 mg
$120.00
1
(1)

Endogenous metabolite influencing TNAP indirectly. 5'-Methylthioadenosine may modulate TNAP activity by affecting cellular signaling pathways or metabolic processes.

Vitamin K3

58-27-5sc-205990B
sc-205990
sc-205990A
sc-205990C
sc-205990D
5 g
10 g
25 g
100 g
500 g
$25.00
$35.00
$46.00
$133.00
$446.00
3
(1)

Vitamin K3 impacts TNAP activity. Menadione, a synthetic form of vitamin K, may inhibit TNAP activity.