TMP21 Antibody (F-7): sc-137004

TMP21 Antibody (F-7) is a mouse monoclonal IgG2a antibody that detects TMP21 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TMP21, also known as TMED10, is a crucial member of the EMP24/GP25L/p24 cargo family of proteins, playing a vital role in regulating vesicular trafficking within the early secretory pathway. TMP21 is predominantly localized to the Golgi cisternae and plasma membrane, where TMP21 functions as a single-pass type I membrane protein. A GOLD (Golgi dynamics) domain within TMP21 facilitates protein transport and quality control between the endoplasmic reticulum and Golgi complex, ensuring that only properly folded and assembled proteins are transported to their destinations. TMP21 is an integral component of the heteromeric secretase complex, also known as the Presenilin complex, where TMP21 modulates γ-secretase activity, a process critical for regulating various signaling pathways and metabolism of amyloid precursor protein. Two isoforms, TMP21-I and TMP21-II, further highlight the complexity and functional diversity of TMP21, making anti-TMP21 antibody (F-7) an essential tool for researchers studying its role in cellular processes and disease mechanisms.

The preferred TMP21 antibody is TMP21 Antibody (A-7): sc-137003.