TIP120A Antibody (G-3): sc-137055

TIP120A Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIP120A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TIP120A antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TIP120A plays a crucial role in transcriptional regulation as TIP120A interacts with the TATA-binding protein (TBP) and a specific subunit of RNA polymerases, facilitating the integration of RNA polymerase II into the preinitiation complex. This interaction is vital for proper assembly of the transcription machinery, ensuring accurate regulation of gene expression. TIP120A, ubiquitously expressed and originally isolated from rat liver nuclear extracts, acts as a global activator in transcriptional regulation alongside TIP120B, which is specifically expressed in muscle tissues. TIP120A′s direct binding to TBP and chaperone-like activity towards RNA polymerases highlight TIP120A′s importance in amplifying gene expression, making TIP120A a significant target for studies related to transcriptional control and gene regulation.

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TIP120A Antibody (G-3) References:

1. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues.  |  Aoki, T., et al. 1999. Biochem Biophys Res Commun. 261: 911-6. PMID: 10441524
2. TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism.  |  Makino, Y., et al. 1999. Mol Cell Biol. 19: 7951-60. PMID: 10567521
3. Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A.  |  Yogosawa, S., et al. 1999. Biochem Biophys Res Commun. 266: 123-8. PMID: 10581176
4. Advances in RNA polymerase II transcription.  |  Zawel, L. and Reinberg, D. 1992. Curr Opin Cell Biol. 4: 488-95. PMID: 1497921
5. The Impact of Cand1 in Prostate Cancer.  |  Eigentler, A., et al. 2020. Cancers (Basel). 12: PMID: 32059441
6. Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.  |  Li, X., et al. 2022. Pharmacol Res. 182: 106284. PMID: 35661710
7. Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.  |  Shaaban, M., et al. 2023. Mol Cell. 83: 2332-2346.e8. PMID: 37339624
8. Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2.  |  Huang, X., et al. 2023. Nat Commun. 14: 4620. PMID: 37528093
9. CAND1 inhibits Cullin-2-RING ubiquitin ligases for enhanced substrate specificity.  |  Wang, K., et al. 2024. Nat Struct Mol Biol. 31: 323-335. PMID: 38177676
10. General initiation factors for RNA polymerase II.  |  Conaway, RC. and Conaway, JW. 1993. Annu Rev Biochem. 62: 161-90. PMID: 8352588
11. The role of general initiation factors in transcription by RNA polymerase II.  |  Roeder, RG. 1996. Trends Biochem Sci. 21: 327-35. PMID: 8870495
12. Molecular cloning of a novel 120-kDa TBP-interacting protein.  |  Yogosawa, S., et al. 1996. Biochem Biophys Res Commun. 229: 612-7. PMID: 8954946

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIP120A Antibody (G-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TIP120A Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIP120A Antibody (G-3) Specifications

Alternate Product Name: TIP120A

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 396-480

Epitope Target: TIP120A

Epitope Species: human

Product Reactivity/Detection: TIP120A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TIP120A Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent