TIAR Antibody (H-1): sc-398373
- TIAR Antibody (H-1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 348-377 near the C-terminus of TIAR of human origin
- recommended for detection of TIAR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TIAR Antibody (H-1) for WB applications. These reagents are now offered in bundles with TIAR Antibody (H-1) (see ordering information below).
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TIAR Antibody (H-1) is a mouse monoclonal IgG2a antibody that detects TIAR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIAR, or T-cell intracellular antigen 1, is a crucial protein involved in the regulation of apoptosis and cellular stress responses, making TIAR significant in the context of viral immunity and cancer biology. TIAR is primarily located in the nucleus, where TIAR plays a vital role in RNA metabolism and the regulation of gene expression. Nuclear localization of TIAR is essential for function in splicing and mRNA stability, as TIAR interacts with various RNA-binding proteins and influences the fate of mRNA during stress conditions. Upon Fas ligation, TIAR rapidly translocates to the cytoplasm, participating in the apoptotic signaling cascade and leading to DNA fragmentation. TIAR′s ability to shuttle between the nucleus and cytoplasm underscores TIAR′s importance in cellular responses to stress and apoptosis, highlighting TIAR′s potential as a therapeutic target in diseases characterized by dysregulated cell death. Anti-TIAR antibody (H-1) is an invaluable tool for researchers studying these critical biological processes.
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TIAR Antibody (H-1) References:
- [Epstein-Barr virus infection and expression of T-cell intracellular antigen-1 (TIA-1) in intestinal T-cell lymphoma]. | Ren, X., et al. 1999. Zhonghua Bing Li Xue Za Zhi. 28: 348-51. PMID: 11869547
- Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. | Li, W., et al. 2002. J Virol. 76: 11989-2000. PMID: 12414941
- TIA-1 or TIAR is required for DT40 cell viability. | Le Guiner, C., et al. 2003. J Biol Chem. 278: 10465-76. PMID: 12533540
- Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis. | Suzuki, E., et al. 2006. Int J Mol Med. 18: 273-8. PMID: 16820934
- Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode. | Kuwasako, K., et al. 2008. Biochemistry. 47: 6437-50. PMID: 18500819
- Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R. | Izquierdo, JM. 2010. Nucleic Acids Res. 38: 8001-14. PMID: 20699271
- Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells. | Carrascoso, I., et al. 2014. Biochem J. 461: 43-50. PMID: 24927121
- Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1). | Wigington, CP., et al. 2015. J Biol Chem. 290: 3468-87. PMID: 25519906
- TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication. | Wang, X., et al. 2015. Biochem Biophys Res Commun. 466: 254-9. PMID: 26363455
- Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules. | Andrusiak, MG., et al. 2019. Neuron. 104: 290-304.e8. PMID: 31378567
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIAR Antibody (H-1) | sc-398373 | 200 µg/ml | $322.00 | |||
TIAR Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-538428 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIAR Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-536041 | 200 µg Ab; 40 µg BP | $361.00 | |||
TIAR Antibody (H-1): m-IgG2a BP-HRP Bundle | sc-548298 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIAR (H-1) Neutralizing Peptide | sc-398373 P | 100 µg/0.5 ml | $69.00 |