Thyroglobulin Antibody (F-7): sc-514301

Thyroglobulin Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects thyroglobulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Thyroglobulin is a large preprotein that plays a crucial role in the synthesis of the iodinated thyroid hormones thyroxine and triiodothyronine, which are essential for regulating metabolism, growth, and development in vertebrates. Anti-thyroglobulin antibody (F-7) targets proteins primarily located in the thyroid gland, where thyroglobulin serves as a storage form of thyroid hormones and is involved in their production. The proper localization and function of thyroglobulin are vital, as any defects can lead to conditions such as goiter, characterized by the enlargement of the thyroid gland. This enlargement is often a result of impaired dimerization and transport of thyroglobulin to the Golgi complex, highlighting the importance of structural integrity and cellular trafficking in maintaining thyroid health. Thyroglobulin monoclonal antibody (F-7) serves as an invaluable tool for researchers studying thyroid function and related disorders, providing reliable detection and analysis of this critical protein.

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Thyroglobulin Antibody (F-7) References:

1. Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.  |  Kohn, LD., et al. 2001. Trends Endocrinol Metab. 12: 10-6. PMID: 11137035
2. Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations.  |  Targovnik, HM., et al. 2010. Mol Cell Endocrinol. 322: 44-55. PMID: 20093166
3. Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.  |  Fernando, R., et al. 2012. Proc Natl Acad Sci U S A. 109: 7427-32. PMID: 22517745
4. Serum thyroglobulin antibody levels within or near to the reference range may interfere with thyroglobulin measurement.  |  Locsei, Z., et al. 2012. Biochem Med (Zagreb). 22: 365-70. PMID: 23092067
5. In vitro studies of the thyroglobulin degradation pathway: endocytosis and delivery of thyroglobulin to lysosomes, release of thyroglobulin cleavage products--iodotyrosines and iodothyronines.  |  Rousset, B., et al. 1989. Biochimie. 71: 247-62. PMID: 2495825
6. Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure.  |  Pyun, JA., et al. 2014. Clin Exp Reprod Med. 41: 120-4. PMID: 25309856
7. Stimulated Thyroglobulin and Thyroglobulin Reduction Index Predict Excellent Response in Differentiated Thyroid Cancers.  |  Barres, B., et al. 2019. J Clin Endocrinol Metab. 104: 3462-3472. PMID: 30785995
8. A Novel Thyroglobulin Immunoassay Using the Specimen-Pretreatment Process Improves the Accuracy of Thyroglobulin Measurements in Anti-Thyroglobulin Positive Specimens.  |  Kitamura, Y., et al. 2021. J Appl Lab Med. 6: 1463-1475. PMID: 34580727
9. Early stimulated thyroglobulin after thyroidectomy for thyroid cancer predicts preradioiodine therapy thyroglobulin values.  |  Valencia, J., et al. 2023. Minerva Endocrinol (Torino). 48: 387-394. PMID: 35822431
10. Comparing the efficacy of thyroglobulin and thyroglobulin/ thyroid-stimulating hormone ratio models in predicting a successful response to radioactive iodine therapy.  |  Ju, Y., et al. 2023. BMC Endocr Disord. 23: 19. PMID: 36670396

The preferred Thyroglobulin antibody is Thyroglobulin Antibody (D-9): sc-365997.