Thyroglobulin Inhibitors
The chemical class denoted as Thyroglobulin inhibitors encompasses a diverse repertoire of compounds strategically designed to exert indirect influence on pathways and cellular processes associated with Thyroglobulin modulation. These inhibitors target a spectrum of signaling cascades, including the RAF/MEK/ERK, PI3K/Akt, JNK, and mTOR pathways, presenting a nuanced approach to unraveling the intricate regulation of Thyroglobulin. One notable member of this class is Sorafenib, a kinase inhibitor with a specific impact on the RAF/MEK/ERK pathway. By disrupting downstream signaling events crucial for cell cycle progression and differentiation, Sorafenib holds the potential to modulate Thyroglobulin levels indirectly. Dasatinib, characterized as a tyrosine kinase inhibitor, exerts its influence on Src family kinases and BCR-ABL, thereby affecting pathways intertwined with cell growth and survival. This indirect modulation has implications for Thyroglobulin levels, as alterations in cellular processes dependent on these signaling cascades may impact the synthesis and regulation of Thyroglobulin. Additionally, Wortmannin, a PI3K inhibitor within this chemical class, disrupts the PI3K/Akt pathway, potentially influencing Thyroglobulin through its impact on cell survival and growth-related processes.
These inhibitors collectively offer valuable insights into the complex interplay of signaling pathways associated with Thyroglobulin modulation. By selectively targeting specific components of these intricate networks, the inhibitors contribute to a more comprehensive understanding of thyroid function. Through their ability to indirectly influence Thyroglobulin levels, they provide researchers with tools to dissect the multifaceted regulatory mechanisms governing thyroid homeostasis. As our comprehension of these pathways expands, so does the potential for developing targeted interventions for thyroid-related disorders, making the study of Thyroglobulin inhibitors pivotal in advancing our understanding of thyroid function and associated pathologies.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib, a kinase inhibitor, influences the RAF/MEK/ERK signaling pathway. By inhibiting RAF kinases, it disrupts downstream signaling cascades, potentially indirectly modulating Thyroglobulin levels through alterations in cellular proliferation and differentiation. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a tyrosine kinase inhibitor, targets Src family kinases and BCR-ABL. Through its action on these kinases, Dasatinib affects signaling pathways involved in cell growth and survival, potentially indirectly impacting Thyroglobulin levels by influencing cellular processes dependent on these pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB202190 is a p38 MAPK inhibitor. By blocking p38 MAPK, it can modulate signaling pathways involved in inflammation and stress responses, potentially indirectly influencing Thyroglobulin levels through alterations in cellular stress responses that may impact thyroid function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that disrupts the PI3K/Akt signaling pathway. By inhibiting PI3K, it interferes with downstream signaling, potentially indirectly modulating Thyroglobulin levels through alterations in cellular processes influenced by the PI3K/Akt pathway, such as cell survival and growth. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662 is a selective PPARγ antagonist. By inhibiting PPARγ, it can impact transcriptional regulation related to metabolic processes, potentially indirectly modulating Thyroglobulin levels by influencing pathways involved in cellular metabolism and differentiation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor. By targeting BET proteins, it can influence gene expression and transcriptional regulation, potentially indirectly modulating Thyroglobulin levels through alterations in the expression of genes involved in thyroid function and differentiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that affects the PI3K/Akt signaling pathway. By inhibiting PI3K, it can modulate downstream signaling cascades, potentially indirectly influencing Thyroglobulin levels through alterations in cellular processes regulated by the PI3K/Akt pathway, such as cell survival and growth. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that targets the JNK signaling pathway. By inhibiting JNK, it can modulate stress-induced signaling cascades, potentially indirectly influencing Thyroglobulin levels through alterations in cellular stress responses and inflammation that may impact thyroid function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that affects the mTOR signaling pathway. By inhibiting mTOR, it can impact protein synthesis and cell growth, potentially indirectly modulating Thyroglobulin levels through alterations in cellular processes dependent on the mTOR pathway, such as cell proliferation and differentiation. | ||||||