Thyroglobulin Antibody (1D4): sc-53543
- Thyroglobulin Antibody (1D4) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against full length Thyroglobulin of human origin
- recommended for detection of Thyroglobulin in hyperplastic and neoplastic thyroid of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Thyroglobulin Antibody (1D4) for WB and IHC(P) applications. These reagents are now offered in bundles with Thyroglobulin Antibody (1D4) (see ordering information below).
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Thyroglobulin Antibody (1D4) is a mouse monoclonal IgG2a antibody that detects thyroglobulin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Thyroglobulin is a crucial protein synthesized in the thyroid gland, serving as the precursor for the iodinated thyroid hormones thyroxine and triiodothyronine, which are essential for regulating metabolism, growth, and development. Anti-thyroglobulin antibody (1D4) enables researchers to study post-translational modifications, including glycosylation, which are necessary for thyroglobulin stability and activity. These modifications facilitate correct folding and maturation of thyroglobulin while playing a significant role in secretion and subsequent hormone synthesis. Disruptions in these processes can lead to conditions such as goiter, characterized by thyroid gland enlargement, often resulting from defective dimerization and transport of thyroglobulin to the Golgi complex. Thyroglobulin monoclonal antibody (1D4) serves as an invaluable tool for researchers studying thyroid function and related disorders, providing insights into molecular mechanisms underlying thyroid hormone synthesis and regulation.
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Thyroglobulin Antibody (1D4) References:
- Delimitation of the time of death by immunohistochemical detection of thyroglobulin. | Wehner, F., et al. 2000. Forensic Sci Int. 110: 199-206. PMID: 10842031
- Preoperative determination of serum thyroglobulin to identify patients with differentiated thyroid cancer who may present recurrence without increased thyroglobulin. | Gibelli, B., et al. 2005. Acta Otorhinolaryngol Ital. 25: 94-9. PMID: 16116831
- Serum thyroglobulin, high-resolution ultrasound, and lymph node thyroglobulin in diagnosis of differentiated thyroid carcinoma nodal metastases. | Snozek, CL., et al. 2007. J Clin Endocrinol Metab. 92: 4278-81. PMID: 17684045
- Heterophile antibodies rarely influence the measurement of thyroglobulin and thyroglobulin antibodies in differentiated thyroid cancer patients. | Verburg, FA., et al. 2010. Horm Metab Res. 42: 736-9. PMID: 20486066
- Significance of Low Levels of Thyroglobulin Autoantibodies Associated with Undetectable Thyroglobulin After Thyroidectomy for Differentiated Thyroid Carcinoma. | Latrofa, F., et al. 2016. Thyroid. 26: 798-806. PMID: 27020734
- Interference of serum thyroglobulin in the radioassay for serum antithyroglobulin antibodies. | Pinchera, A., et al. 1977. J Clin Endocrinol Metab. 45: 1077-88. PMID: 579182
- The acute changes in thyroid stimulating immunoglobulins, thyroglobulin and thyroglobulin antibodies following subtotal thyroidectomy. | Bech, K., et al. 1982. Clin Endocrinol (Oxf). 16: 235-42. PMID: 6122518
- Thyroglobulin structure-function: the effect of iodination on the structure of human thyroglobulin. | Zabel, KM. and Rawitch, AB. 1984. Biochem Biophys Res Commun. 121: 310-6. PMID: 6732810
- Concentration of thyroglobulin, iodine contents of thyroglobulin and of iodoaminoacids in human neonates thyroid glands. | Etling, N. 1977. Acta Paediatr Scand. 66: 97-102. PMID: 831387
- Identification of the membrane receptor binding domain of thyroglobulin. Insights into quality control of thyroglobulin biosynthesis. | Mezghrani, A., et al. 1997. J Biol Chem. 272: 23340-6. PMID: 9287346
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thyroglobulin Antibody (1D4) | sc-53543 | 200 µg/ml | $316.00 | |||
Thyroglobulin Antibody (1D4): m-IgG Fc BP-HRP Bundle | sc-536984 | 200 µg Ab; 10 µg BP | $354.00 | |||
Thyroglobulin Antibody (1D4): m-IgGκ BP-HRP Bundle | sc-534163 | 200 µg Ab; 40 µg BP | $354.00 | |||
Thyroglobulin Antibody (1D4): m-IgG2a BP-HRP Bundle | sc-547911 | 200 µg Ab; 10 µg BP | $354.00 |