Thrombospondin 4 Antibody (G-6): sc-55464

Thrombospondin 4 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects Thrombospondin 4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Thrombospondin 4 is primarily expressed in the nervous system and plays a crucial role in neuronal development and repair, particularly by stimulating neurite outgrowth, which is essential for the formation of neural networks and the recovery of damaged neurons. Anti-Thrombospondin 4 antibody (G-6) enables researchers to study this protein′s ability to promote neurite extension, which is vital for proper neuronal connectivity and function, making Thrombospondin 4 a key player in neurodevelopmental processes and potential therapeutic target for neurodegenerative diseases. Thrombospondin 4 also interacts with various extracellular matrix components and growth factors, further underscoring its importance in cellular signaling and tissue repair mechanisms. Thrombospondin 4 (G-6) antibody serves as an invaluable tool for researchers studying neuronal biology and related fields.

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Thrombospondin 4 Antibody (G-6) References:

1. Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling.  |  Mustonen, E., et al. 2012. Ann Med. 44: 793-804. PMID: 22380695
2. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.  |  Subramanian, A. and Schilling, TF. 2014. Elife. 3: PMID: 24941943
3. The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage.  |  Maly, K., et al. 2019. Int J Mol Sci. 20: PMID: 30669608
4. Thrombospondin-4 expression as a prognostic marker in hepatocellular carcinoma.  |  Wu, H., et al. 2019. Gene. 696: 219-224. PMID: 30802535
5. The P387 thrombospondin-4 variant promotes accumulation of macrophages in atherosclerotic lesions.  |  Muppala, S., et al. 2020. FASEB J. 34: 11529-11545. PMID: 32686880
6. Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells.  |  Shi, Y., et al. 2021. J Exp Clin Cancer Res. 40: 14. PMID: 33407730
7. Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.  |  Andrés Sastre, E., et al. 2021. Bone. 150: 115999. PMID: 33971315
8. Thrombospondin-4 as potential cerebrospinal fluid biomarker for therapy response in pediatric spinal muscular atrophy.  |  Dobelmann, V., et al. 2024. J Neurol. 271: 7000-7011. PMID: 39240344
9. Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles.  |  Cassioli, C., et al. 2025. Proc Natl Acad Sci U S A. 122: e2413866122. PMID: 39903110
10. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.  |  Lawler, J., et al. 1993. J Cell Biol. 120: 1059-67. PMID: 8432726

The preferred Thrombospondin 4 antibody is Thrombospondin 4 Antibody (F-7): sc-390734.