Thrombospondin 4 Antibody (F-7): sc-390734

Thrombospondin 4 Antibody (F-7) is a mouse monoclonal IgM antibody that detects Thrombospondin 4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Thrombospondin 4 antibody (F-7) is available as a non-conjugated format. Thrombospondin 4, a member of the thrombospondin family of glycoproteins, plays a crucial role in the nervous system, particularly in promoting neurite outgrowth, which is essential for neuronal development and regeneration. Thrombospondin 4 is primarily expressed in neurons and is involved in modulating cell signaling pathways that influence neuronal survival and differentiation. Thrombospondin 4′s ability to stimulate neurite outgrowth is vital for neural network formation and damaged tissue repair, making Thrombospondin 4 a significant factor in neurodevelopmental processes and potential therapeutic targets for neurodegenerative diseases. Thrombospondin 4 interacts with various extracellular matrix components and growth factors, further underscoring Thrombospondin 4′s importance in cellular communication and tissue homeostasis.

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Thrombospondin 4 Antibody (F-7) References:

1. Thrombospondin-4 binds specifically to both collagenous and non-collagenous extracellular matrix proteins via its C-terminal domains.  |  Narouz-Ott, L., et al. 2000. J Biol Chem. 275: 37110-7. PMID: 10956668
2. Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.  |  O'Rourke, KM., et al. 1992. J Biol Chem. 267: 24921-4. PMID: 1459996
3. Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.  |  LaBell, TL., et al. 1992. Genomics. 12: 421-9. PMID: 1559694
4. Physiology of thrombospondin.  |  Mosher, DF. 1990. Annu Rev Med. 41: 85-97. PMID: 1691903
5. A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome.  |  Bornstein, P., et al. 1991. J Biol Chem. 266: 12821-4. PMID: 1712771
6. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.  |  Kim, DS., et al. 2012. J Neurosci. 32: 8977-87. PMID: 22745497
7. The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer.  |  Kuroda, K., et al. 2019. PLoS One. 14: e0224727. PMID: 31703077
8. New Biomarkers (Endocan, Interleukin-17, and Thrombospondin-4) for the Diagnosis, Assessment of Severity, and Follow-Up of Peripheral Arterial Disease.  |  Yazman, S., et al. 2023. Angiology. 74: 631-639. PMID: 37010303
9. Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth.  |  Arber, S. and Caroni, P. 1995. J Cell Biol. 131: 1083-94. PMID: 7490284
10. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues.  |  Qabar, A., et al. 1995. J Biol Chem. 270: 12725-9. PMID: 7759526
11. The functions of thrombospondin and its involvement in physiology and pathophysiology.  |  Lahav, J. 1993. Biochim Biophys Acta. 1182: 1-14. PMID: 8347680
12. Thrombospondin-1.  |  Adams, JC. 1997. Int J Biochem Cell Biol. 29: 861-5. PMID: 9304800

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Thrombospondin 4 Antibody (F-7) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Thrombospondin 4 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Thrombospondin 4 Antibody (F-7) Specifications

Alternate Product Name: Thrombospondin 4

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 930-961

Epitope Target: Thrombospondin 4

Epitope Species: human

Product Reactivity/Detection: Thrombospondin 4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Thrombospondin 4 Antibody (F-7): P: Blocking Peptide