TGF beta Receptor 2/TGFBR2 Antibody (D-2): sc-17799
- TGF beta Receptor 2/TGFBR2 Antibody (D-2) is a mouse monoclonal IgG2b κ, cited in 42 publications, provided at 200 µg/ml
- raised against amino acids 1-567 representing full length TFGβ RII of human origin
- Anti-TGF beta Receptor 2/TGFBR2 Antibody (D-2) is recommended for detection of TGFβ RII of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TGF beta Receptor 2/TGFBR2 Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TGF beta Receptor 2/TGFBR2 Antibody (D-2) for WB and IHC(P) applications. These reagents are now offered in bundles with TGF beta Receptor 2/TGFBR2 Antibody (D-2) (see ordering information below).
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TGFβ RII Antibody (D-2) is a mouse monoclonal IgG2b kappa light chain antibody engineered to recognize the transforming growth factor beta receptor type II (TGFβ RII), also known as TGFBR2, in human, mouse, and rat species. TGFβ RII monoclonal antibody (D-2) targets the full-length human TGFβ RII protein, spanning amino acids 1-567, and is suitable for a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TGFβ RII is a single-pass type I transmembrane protein that plays a crucial role in the TGF-beta signaling pathway, which is essential for regulating cellular processes such as growth, differentiation, and apoptosis. The structural integrity of TGFβ RII, characterized by its extracellular ligand-binding domain and intracellular serine-threonine kinase domain, is vital for its function in signal transduction. Upon binding to TGF-beta ligands, TGFβ RII undergoes dimerization and phosphorylation, facilitating the recruitment and activation of type I receptors, which then propagate the signal through downstream Smad proteins to modulate gene expression. This structural mechanism is fundamental for maintaining cellular homeostasis and has significant implications in various physiological and pathological contexts, including cancer, fibrosis, and immune regulation. Anti-TGFβ RII antibody (D-2) is available in both conjugated and non-conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants, providing flexibility for diverse research needs. TGFβ RII (D-2) monoclonal antibody supports advanced studies into the complexities of TGF-beta signaling pathways and their role in disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TGF beta Receptor 2/TGFBR2 Antibody (D-2) | sc-17799 | 200 µg/ml | $316.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-528318 | 200 µg Ab; 10 µg BP | $354.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-520663 | 200 µg Ab, 40 µg BP | $354.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2): m-IgG2b BP-HRP Bundle | sc-550027 | 200 µg Ab; 10 µg BP | $354.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) AC | sc-17799 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) HRP | sc-17799 HRP | 200 µg/ml | $316.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) FITC | sc-17799 FITC | 200 µg/ml | $330.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) PE | sc-17799 PE | 200 µg/ml | $343.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 488 | sc-17799 AF488 | 200 µg/ml | $357.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 546 | sc-17799 AF546 | 200 µg/ml | $357.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 594 | sc-17799 AF594 | 200 µg/ml | $357.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 647 | sc-17799 AF647 | 200 µg/ml | $357.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 680 | sc-17799 AF680 | 200 µg/ml | $357.00 | |||
TGF beta Receptor 2/TGFBR2 Antibody (D-2) Alexa Fluor® 790 | sc-17799 AF790 | 200 µg/ml | $357.00 |