TGase4 Antibody (C-11): sc-514801

TGase4 Antibody (C-11) is a mouse monoclonal IgG2b antibody that detects TGase4 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TGase4, also known as TGM4, TGP, or hTGP, plays a crucial role in forming the cross-linked cell envelope, a vital component of the epidermis that provides structural integrity and barrier function to the skin. TGase4 is specifically expressed in prostate tissue and catalyzes the formation of isopeptide bonds through transglutaminase activity, which is essential for various biological processes, including epidermal differentiation and cell apoptosis. The unique structure of TGase4, characterized by its catalytic domain and substrate-binding sites, allows interaction with specific proteins, facilitating the cross-linking of glutamine and lysine residues. This interaction contributes to the stabilization of the extracellular matrix and regulation of cellular functions, making TGase4 a key player in maintaining tissue homeostasis and responding to physiological changes. Anti-TGase4 antibody (C-11) serves as an invaluable tool for researchers studying skin biology, prostate function, and related pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TGase4 Antibody (C-11) References:

1. A sensitive fluorometric assay for tissue transglutaminase.  |  Jeitner, TM., et al. 2001. Anal Biochem. 292: 198-206. PMID: 11355851
2. Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer.  |  Davies, G., et al. 2007. J Exp Ther Oncol. 6: 257-64. PMID: 17552366
3. The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway.  |  Jiang, WG., et al. 2009. Microvasc Res. 77: 150-7. PMID: 18983858
4. Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.  |  Cho, SY., et al. 2010. Exp Mol Med. 42: 310-8. PMID: 20177144
5. Monoclonal antibodies to human transglutaminase 4.  |  Cho, SY., et al. 2010. Hybridoma (Larchmt). 29: 263-7. PMID: 20569004
6. The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells.  |  Jiang, WG., et al. 2010. Int J Oncol. 37: 413-8. PMID: 20596668
7. Overexpression of transglutaminase 4 and prostate cancer progression: a potential predictor of less favourable outcomes.  |  Cao, Z., et al. 2013. Asian J Androl. 15: 742-6. PMID: 23974364
8. Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain.  |  Jiang, WG., et al. 2013. J Transl Med. 11: 269. PMID: 24161123
9. The prostate-specific protein, transglutaminase 4 (TG4), is an autoantigen associated with male subfertility.  |  Iismaa, SE. 2016. Ann Transl Med. 4: S35. PMID: 27868003
10. TGM4: an immunogenic prostate-restricted antigen.  |  Lopez-Bujanda, ZA., et al. 2021. J Immunother Cancer. 9: PMID: 34193566

The preferred TGase4 antibody is TGase4 Antibody (E-10): sc-271382.