TFIIH p62 Antibody (G-10): sc-48431

TFIIH p62 Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects TFIIH p62 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TFIIH p62 plays a crucial role in the nucleotide excision repair pathway, which maintains genomic stability by repairing DNA damage caused by environmental factors such as UV radiation and chemical exposure. TFIIH p62 is located in the nucleus, where TFIIH p62 functions as part of the larger TFIIH complex, facilitating transcription initiation by RNA polymerase II and providing helicase activity that unwinds DNA during repair processes. TFIIH p62 is vital for proper cellular mechanisms, as deficiencies or mutations can lead to increased susceptibility to cancer and other genetic disorders. Anti-TFIIH p62 antibody (G-10) serves as an invaluable tool for researchers studying transcription and DNA repair, providing insights into molecular underpinnings of cellular responses to DNA damage.

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TFIIH p62 Antibody (G-10) References:

1. Assignment of the 1H, 15N, 13C resonances of the N-terminal domain of the human TFIIH P62 subunit.  |  Gervais, V., et al. 2001. J Biomol NMR. 19: 281-2. PMID: 11330817
2. p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription.  |  Liu, Y., et al. 2005. Mol Endocrinol. 19: 879-84. PMID: 15625236
3. NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.  |  Kalveram, B., et al. 2011. J Virol. 85: 6234-43. PMID: 21543505
4. Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.  |  Kainulainen, M., et al. 2014. J Virol. 88: 3464-73. PMID: 24403578
5. Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.  |  Akimoto, Y., et al. 2014. Genes Cells. 19: 879-90. PMID: 25308091
6. Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit.  |  Okuda, M. and Nishimura, Y. 2015. Oncogenesis. 4: e150. PMID: 26029824
7. Dataset for the NMR structure of the intrinsically disordered acidic region of XPC bound to the PH domain of TFIIH p62.  |  Okuda, M. and Nishimura, Y. 2016. Data Brief. 6: 571-7. PMID: 26909369
8. Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins.  |  Ly, HJ. and Ikegami, T. 2016. Virol J. 13: 118. PMID: 27368371
9. DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.  |  Ribeiro-Silva, C., et al. 2018. Nat Commun. 9: 4067. PMID: 30287812
10. The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer.  |  Kitamura, K., et al. 2023. Int J Mol Sci. 24: PMID: 38139171

The preferred TFIIH p62 antibody is TFIIH p62 Antibody (H-10): sc-25329.