TFIIB Antibody (IIB1): sc-56793
- TFIIB Antibody (IIB1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against TFIIB of human origin
- recommended for detection of TFIIB of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TFIIB Antibody (IIB1) for WB applications. These reagents are now offered in bundles with TFIIB Antibody (IIB1) (see ordering information below).
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SEE ALSO...
TFIIB Antibody (IIB1) is a mouse monoclonal IgG2b antibody that detects TFIIB in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). TFIIB plays a crucial role in the initiation of transcription by RNA polymerase II, acting as a key bridge between the transcription machinery and the core promoter elements, particularly the TATA box. This interaction is vital for the formation of the pre-initiation complex, which is essential for accurate and efficient transcription of protein-coding genes. Anti-TFIIB antibody (IIB1) facilitates research into the recruitment of RNA polymerase II to the promoter region, highlighting TFIIB′s importance in regulating gene expression, as disruption in this process can lead to aberrant transcription and has been implicated in various diseases, including cancer. TFIIB monoclonal antibody (IIB1) serves as an invaluable tool for researchers studying transcriptional regulation and the molecular mechanisms underlying gene expression in eukaryotic systems.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TFIIB Antibody (IIB1) References:
- Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection. | Fairley, JA., et al. 2002. Mol Cell Biol. 22: 6697-705. PMID: 12215527
- Interdependent interactions between TFIIB, TATA binding protein, and DNA. | Buratowski, RM., et al. 2002. Mol Cell Biol. 22: 8735-43. PMID: 12446790
- Phosphorylation of TFIIB links transcription initiation and termination. | Wang, Y., et al. 2010. Curr Biol. 20: 548-53. PMID: 20226668
- TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response. | Shandilya, J., et al. 2012. Proc Natl Acad Sci U S A. 109: 18797-802. PMID: 23115335
- Emergence and expansion of TFIIB-like factors in the plant kingdom. | Knutson, BA. 2013. Gene. 526: 30-8. PMID: 23608173
- A new paradigm for transcription factor TFIIB functionality. | Gelev, V., et al. 2014. Sci Rep. 4: 3664. PMID: 24441171
- TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma. | Sui, R., et al. 2021. Biochem Biophys Res Commun. 540: 95-100. PMID: 33453679
- TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth. | Wang, J., et al. 2023. Hum Mol Genet. 32: 104-121. PMID: 35925837
- TFIIB-Related Protein BRP5/PTF2 Is Required for Both Male and Female Gametogenesis and for Grain Formation in Rice. | Chen, G., et al. 2023. Int J Mol Sci. 24: PMID: 38003663
- The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infection. | Gulyas, L. and Glaunsinger, BA. 2024. bioRxiv.. PMID: 38746429
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFIIB Antibody (IIB1) | sc-56793 | 200 µg/ml | $322.00 | |||
TFIIB Antibody (IIB1): m-IgG Fc BP-HRP Bundle | sc-537119 | 200 µg Ab; 10 µg BP | $361.00 | |||
TFIIB Antibody (IIB1): m-IgGκ BP-HRP Bundle | sc-534311 | 200 µg Ab; 40 µg BP | $361.00 | |||
TFIIB Antibody (IIB1): m-IgG2b BP-HRP Bundle | sc-549857 | 200 µg Ab; 10 µg BP | $361.00 |