TFEB Antibody (17): sc-101532
- TFEB Antibody (17) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant TFEB of human origin
- recommended for detection of TFEB of human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TFEB Antibody (17) for WB applications. These reagents are now offered in bundles with TFEB Antibody (17) (see ordering information below).
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TFEB Antibody (17) is a mouse monoclonal IgG1 antibody that detects TFEB in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TFEB, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a pivotal role in cellular processes, particularly in the regulation of lysosomal biogenesis and autophagy. TFEB is primarily located in the nucleus, where TFEB functions as a transcriptional regulator, responding to various cellular stressors and nutrient signals. Nuclear localization of TFEB is crucial because TFEB effectively modulates gene expression in response to metabolic changes, thereby influencing cellular homeostasis and survival. TFEB can translocate to the cytoplasm under certain conditions, which is essential for TFEB′s role in autophagy and lysosomal function. Dysregulation of TFEB has been implicated in various diseases, including neurodegenerative disorders and cancer, making TFEB a significant target for therapeutic intervention. Anti-TFEB antibody (17) is an invaluable tool for researchers aiming to explore the intricate mechanisms of cellular regulation and the implications of TFEB in health and disease.
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TFEB Antibody (17) References:
- TFEB links autophagy to lysosomal biogenesis. | Settembre, C., et al. 2011. Science. 332: 1429-33. PMID: 21617040
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. | Medina, DL., et al. 2015. Nat Cell Biol. 17: 288-99. PMID: 25720963
- STUB1 regulates TFEB-induced autophagy-lysosome pathway. | Sha, Y., et al. 2017. EMBO J. 36: 2544-2552. PMID: 28754656
- Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. | Rusmini, P., et al. 2019. Autophagy. 15: 631-651. PMID: 30335591
- Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity. | Yang, S., et al. 2023. Autophagy. 19: 822-838. PMID: 35941759
- TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator. | Franco-Juárez, B., et al. 2022. Cells. 11: PMID: 36231114
- Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction. | Lu, Y., et al. 2023. Autophagy. 19: 1803-1820. PMID: 36588318
- Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. | Cui, Z., et al. 2023. Nature. 614: 572-579. PMID: 36697823
- Hederagenin improves Alzheimer's disease through PPARα/TFEB-mediated autophagy. | Xie, ZS., et al. 2023. Phytomedicine. 112: 154711. PMID: 36809694
- TFEB safeguards trophoblast syncytialization in humans and mice. | Zheng, W., et al. 2024. Proc Natl Acad Sci U S A. 121: e2404062121. PMID: 38968109
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFEB Antibody (17) | sc-101532 | 200 µg/ml | $322.00 | |||
TFEB Antibody (17): m-IgG Fc BP-HRP Bundle | sc-537309 | 200 µg Ab; 10 µg BP | $361.00 | |||
TFEB Antibody (17): m-IgGκ BP-HRP Bundle | sc-534544 | 200 µg Ab; 40 µg BP | $361.00 | |||
TFEB Antibody (17): m-IgG1 BP-HRP Bundle | sc-545129 | 200 µg Ab; 20 µg BP | $361.00 |