TF Antibody (C-7): sc-393657

TF Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Tissue Factor (TF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TF antibody (C-7) recognizes TF, a critical cell surface glycoprotein that plays a pivotal role in initiating the blood coagulation cascade. Located on the surface of various cells, including endothelial cells and monocytes, TF acts as a high-affinity receptor for coagulation Factor VII, facilitating the activation of the extrinsic pathway of coagulation. This pathway is essential for hemostasis, particularly in response to vascular injury, as TF rapidly triggers the formation of a fibrin clot to prevent excessive bleeding. The interaction of TF with Factor VII is crucial, as this binding not only enhances the activation of Factor VII to Factor VIIa but also significantly amplifies the coagulation response, underscoring TF′s importance in maintaining hemostatic balance. TF (C-7) antibody serves as an invaluable tool for researchers studying coagulation processes and related disorders, providing insights into the mechanisms of thrombosis and potential therapeutic targets.

The preferred TF antibody is TF Antibody (H-9): sc-374441.