TF Antibody (H-9): sc-374441
- TF Antibody (H-9) is a mouse monoclonal IgG2b κ TF antibody, cited in 19 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 125-163 within an internal region of TF of mouse origin
- TF Antibody (H-9) is recommended for detection of TF of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TF Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TF Antibody (H-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with TF Antibody (H-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TF Antibody (H-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects TF protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TF Antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tissue factor (TF), also known as coagulation Factor III, is a critical cell surface glycoprotein that plays a pivotal role in hemostasis by initiating the blood coagulation cascade upon tissue injury. TF acts as a high-affinity receptor for coagulation Factor VII, which, when activated, forms a complex that triggers the activation of downstream coagulation factors, ultimately leading to the formation of fibrin clots and platelet aggregation. Proper functioning of TF is essential for maintaining hemostatic balance, as dysregulation can lead to pathological conditions such as thrombosis or hemorrhage. Understanding TF′s role in coagulation not only highlights its importance in normal physiological processes but also underscores TF′s potential as a therapeutic target in various coagulation disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TF Antibody (H-9) References:
- Crystal structures of the membrane-binding C2 domain of human coagulation factor V. | Macedo-Ribeiro, S., et al. 1999. Nature. 402: 434-9. PMID: 10586886
- Tissue factor signaling. | Ruf, W. and Mueller, BM. 1999. Thromb Haemost. 82: 175-82. PMID: 10605702
- The coagulation cascade: initiation, maintenance, and regulation. | Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
- Basic mechanisms in blood coagulation. | Davie, EW. and Fujikawa, K. 1975. Annu Rev Biochem. 44: 799-829. PMID: 237463
- Tissue factor as a link between inflammation and coagulation. | Witkowski, M., et al. 2016. Trends Cardiovasc Med. 26: 297-303. PMID: 26877187
- Role of Tissue Factor in Vascular Failure. | Inoue, T., et al. 2018. Circ J. 82: 1255-1257. PMID: 29618681
- Tissue factor pathway inhibitor in atherosclerosis. | Yuan, HQ., et al. 2019. Clin Chim Acta. 491: 97-102. PMID: 30695687
- Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin. | Kane, WH. and Davie, EW. 1986. Proc Natl Acad Sci U S A. 83: 6800-4. PMID: 3092220
- Complete cDNA and derived amino acid sequence of human factor V. | Jenny, RJ., et al. 1987. Proc Natl Acad Sci U S A. 84: 4846-50. PMID: 3110773
- Tissue factor: a neglected role in cancer biology. | Li, H., et al. 2022. J Thromb Thrombolysis. 54: 97-108. PMID: 35763169
- Tissue Factor and COVID-19: An Update. | Sachetto, ATA. and Mackman, N. 2022. Curr Drug Targets. 23: 1573-1577. PMID: 36165519
- Platelet coagulation factor Va: the major secretory platelet phosphoprotein. | Rand, MD., et al. 1994. Blood. 83: 2180-90. PMID: 8161784
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TF Antibody (H-9) | sc-374441 | 200 µg/ml | $322.00 | |||
TF Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-522739 | 200 µg Ab, 40 µg BP | $361.00 | |||
TF Antibody (H-9) AC | sc-374441 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TF Antibody (H-9) HRP | sc-374441 HRP | 200 µg/ml | $322.00 | |||
TF Antibody (H-9) FITC | sc-374441 FITC | 200 µg/ml | $336.00 | |||
TF Antibody (H-9) PE | sc-374441 PE | 200 µg/ml | $349.00 | |||
TF Antibody (H-9) Alexa Fluor® 488 | sc-374441 AF488 | 200 µg/ml | $364.00 | |||
TF Antibody (H-9) Alexa Fluor® 546 | sc-374441 AF546 | 200 µg/ml | $364.00 | |||
TF Antibody (H-9) Alexa Fluor® 594 | sc-374441 AF594 | 200 µg/ml | $364.00 | |||
TF Antibody (H-9) Alexa Fluor® 647 | sc-374441 AF647 | 200 µg/ml | $364.00 | |||
TF Antibody (H-9) Alexa Fluor® 680 | sc-374441 AF680 | 200 µg/ml | $364.00 | |||
TF Antibody (H-9) Alexa Fluor® 790 | sc-374441 AF790 | 200 µg/ml | $364.00 | |||
TF (H-9) Neutralizing Peptide | sc-374441 P | 100 µg/0.5 ml | $69.00 |