Teneurin-1 Antibody (B-1): sc-398018

Teneurin-1 Antibody (B-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Teneurin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Teneurin-1 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Teneurin-1, also known as tenascin M1 (TEN-M1), TNM, ODZ1, or ODZ3, is a 2,725 amino acid single-pass type II membrane protein that plays a crucial role in cellular signaling and is primarily localized to the membrane of fetal brain cells. Teneurin-1 exists as a disulfide-linked homodimer and features a complex structure that includes eight epidermal growth factor-like domains, twenty-three YD repeats, five NHL repeats, and a Teneurin N-terminal domain, which are essential for mediating cell-cell interactions and signaling pathways. Proline-rich regions in the cytoplasmic domain suggest potential interactions with SH3-containing proteins, highlighting Teneurin-1′s importance in various signaling cascades. The gene encoding Teneurin-1 is located on human chromosome Xq25 and mouse chromosome X A4, making Teneurin-1 a significant focus for studies related to neurodevelopment and potential implications in neurological disorders.

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Teneurin-1 Antibody (B-1) References:

1. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.  |  Ben-Zur, T. and Wides, R. 1999. Genomics. 58: 102-3. PMID: 10331952
2. Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.  |  Minet, AD., et al. 1999. J Cell Sci. 112 (Pt 12): 2019-32. PMID: 10341219
3. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.  |  Ben-Zur, T., et al. 2000. Dev Biol. 217: 107-20. PMID: 10625539
4. The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.  |  Zhou, XH., et al. 2003. Gene Expr Patterns. 3: 397-405. PMID: 12915301
5. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix.  |  Nunes, SM., et al. 2005. Exp Cell Res. 305: 122-32. PMID: 15777793
6. Teneurin-1 is expressed in interconnected regions of the developing brain and is processed in vivo.  |  Kenzelmann, D., et al. 2008. BMC Dev Biol. 8: 30. PMID: 18366734
7. Congenital acquired immunodeficiency syndrome presenting as cor pulmonale in a 10-year-old girl.  |  Hays, MD., et al. 1991. Am Heart J. 121: 929-31. PMID: 2000766
8. Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter.  |  Beckmann, J., et al. 2011. BMC Dev Biol. 11: 35. PMID: 21651764
9. Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior.  |  Chen, Y., et al. 2013. Front Neurosci. 7: 166. PMID: 24062636
10. Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion.  |  Husić, M., et al. 2019. Front Endocrinol (Lausanne). 10: 22. PMID: 30774623
11. Alternative splicing of latrophilin-3 controls synapse formation.  |  Wang, S., et al. 2024. Nature. 626: 128-135. PMID: 38233523
12. Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching.  |  Xu, C., et al. 2024. Cell. 187: 5081-5101.e19. PMID: 38996528

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Teneurin-1 Antibody (B-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Teneurin-1 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Teneurin-1 Antibody (B-1) Specifications

Alternate Product Name: Teneurin-1

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 26-135

Epitope Target: Teneurin-1

Epitope Species: human

Product Reactivity/Detection: Teneurin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Teneurin-1 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin