Tenascin-X Antibody (H-10): sc-166456

Tenascin-X Antibody (H-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects human Tenascin-X by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Tenascin-X antibody (H-10) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Tenascin-X (H-10) antibody targets a member of the tenascin family of extracellular matrix proteins, which includes tenascin-C and tenascin-R, and plays a crucial role in regulating cell adhesion and migration during developmental processes such as morphogenesis and organogenesis. Tenascin-X is primarily located in the extracellular matrix, where Tenascin-X contributes to structural integrity and elasticity of tissues, particularly during embryonic development and in adult tissues undergoing remodeling, such as in wound healing and tumor progression. Tenascin-X (H-10) monoclonal antibody recognizes a protein that interacts with various molecules, including fibronectin and integrins, which are essential for cellular signaling and communication within the extracellular matrix. Tenascin-X′s ability to modulate these interactions highlights its importance in maintaining tissue homeostasis and responding to injury, making Tenascin-X a significant target for research in developmental biology and cancer studies.

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Tenascin-X Antibody (H-10) References:

1. Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome.  |  Bristow, J., et al. 2005. Am J Med Genet C Semin Med Genet. 139C: 24-30. PMID: 16278880
2. Tenascin-X, collagen, and Ehlers-Danlos syndrome: tenascin-X gene defects can protect against adverse cardiovascular events.  |  Petersen, JW. and Douglas, JY. 2013. Med Hypotheses. 81: 443-7. PMID: 23830591
3. Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer.  |  Kramer, M., et al. 2015. Biomed Res Int. 2015: 208017. PMID: 26090390
4. Tenascin-X, Congenital Adrenal Hyperplasia, and the CAH-X Syndrome.  |  Miller, WL. and Merke, DP. 2018. Horm Res Paediatr. 89: 352-361. PMID: 29734195
5. Measurement of Serum Tenascin-X in Joint Hypermobility Syndrome Patients.  |  Yamada, K., et al. 2019. Biol Pharm Bull. 42: 1596-1599. PMID: 31474720
6. Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-β Signaling.  |  Liang, G., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 1748-1763. PMID: 38934115
7. The perplexing multifunctionality of janusin, a tenascin-related molecule.  |  Schachner, M., et al. 1994. Perspect Dev Neurobiol. 2: 33-41. PMID: 7530142
8. Tenascins, a growing family of extracellular matrix proteins.  |  Chiquet-Ehrismann, R. 1995. Experientia. 51: 853-62. PMID: 7556567
9. Astrocytes and neurons regulate the expression of the neural recognition molecule janusin by cultured oligodendrocytes.  |  Jung, M., et al. 1993. Glia. 9: 163-75. PMID: 8294147
10. Characterization of the bovine tenascin-X.  |  Elefteriou, F., et al. 1997. J Biol Chem. 272: 22866-74. PMID: 9278449
11. The tenascin gene family in axon growth and guidance.  |  Faissner, A. 1997. Cell Tissue Res. 290: 331-41. PMID: 9321695
12. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R.  |  Srinivasan, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 15753-7. PMID: 9861042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tenascin-X Antibody (H-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Tenascin-X Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tenascin-X Antibody (H-10) Specifications

Alternate Product Name: Tenascin X (TNX)

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 3881-3970

Epitope Target: Tenascin-X

Epitope Species: human

Product Reactivity/Detection: Tenascin-X

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Tenascin-X Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Tenascin-X antibody is Tenascin-X Antibody (F-11): sc-271594.