Tenascin-X Antibody (F-11): sc-271594

Tenascin-X Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tenascin-X protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Tenascin-X (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Tenascin-X is a crucial extracellular matrix glycoprotein that plays a significant role in tissue development and repair, particularly in regulating cell adhesion and migration during embryogenesis and wound healing. Tenascin-X′s unique structure, characterized by multiple fibronectin type III repeats and EGF-like domains, allows interaction with various cell types and extracellular matrix components, facilitating dynamic processes of tissue remodeling. Tenascin-X influences fibroblast behavior and other cells involved in healing processes, making anti-Tenascin-X antibody (F-11) valuable for studying both normal physiological and pathological conditions, such as fibrosis and tumor progression. Tenascin-X′s ability to modulate cellular responses underscores its importance in maintaining tissue integrity and function, highlighting anti-Tenascin-X antibody (F-11)′s relevance in research focused on developmental biology, regenerative medicine, and cancer studies.

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Tenascin-X Antibody (F-11) References:

1. Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition.  |  Mao, JR., et al. 2002. Nat Genet. 30: 421-5. PMID: 11925569
2. Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X.  |  Zweers, MC., et al. 2006. Circulation. 113: 1702-7. PMID: 16567571
3. Tenascin-X increases the stiffness of collagen gels without affecting fibrillogenesis.  |  Margaron, Y., et al. 2010. Biophys Chem. 147: 87-91. PMID: 20089348
4. Tenascin-X haploinsufficiency associated with Ehlers-Danlos syndrome in patients with congenital adrenal hyperplasia.  |  Merke, DP., et al. 2013. J Clin Endocrinol Metab. 98: E379-87. PMID: 23284009
5. Transforming growth factor-β (TGF-β) pathway abnormalities in tenascin-X deficiency associated with CAH-X syndrome.  |  Morissette, R., et al. 2014. Eur J Med Genet. 57: 95-102. PMID: 24380766
6. Tenascin-X gene defects and cardiovascular disease.  |  Morissette, R., et al. 2014. Med Hypotheses. 83: 844. PMID: 24709065
7. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β.  |  Alcaraz, LB., et al. 2014. J Cell Biol. 205: 409-28. PMID: 24821840
8. The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.  |  Aktar, R., et al. 2018. J Physiol. 596: 4237-4251. PMID: 29917237
9. Recurrent pneumothorax in a case of tenascin-X deficient Ehlers-Danlos syndrome: Broadening the phenotypic spectrum.  |  Santoreneos, R., et al. 2022. Am J Med Genet A. 188: 1583-1588. PMID: 35128805
10. Congenital adrenal hyperplasia with a CYP21A2 deletion overlapping the tenascin-X gene: an atypical presentation.  |  Ivo, CR., et al. 2023. J Pediatr Endocrinol Metab. 36: 81-85. PMID: 36259452

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tenascin-X Antibody (F-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Tenascin-X Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tenascin-X Antibody (F-11) Specifications

Alternate Product Name: Tenascin X (TNX)

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 4231-4244

Epitope Target: Tenascin-X

Epitope Species: human

Product Reactivity/Detection: Tenascin-X

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Tenascin-X Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Tenascin-X antibody is Tenascin-X Antibody (H-10): sc-166456.