t-GMP Antibody (48A10): sc-21726

t-GMP Antibody (48A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects t-GMP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). t-GMP (48A10) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. t-GMP protein plays a crucial role in the Golgi complex, specifically localizing to the trans-most cisternae and trans-tubular network, which is vital for proper sorting and modification of proteins as they transit through the Golgi apparatus. This localization ensures proteins receive necessary post-translational modifications, such as glycosylation and phosphorylation, essential for stability, activity, and eventual delivery to functional destinations within cells. The Golgi complex′s distinct compartments, including cis, medial, and trans Golgi networks, contain specific enzymes that facilitate these modifications, underscoring t-GMP′s precise localization in maintaining cellular homeostasis and function. Treatment with fungal metabolite brefeldin A can disrupt this organization, leading to t-GMP translocation back to the endoplasmic reticulum, highlighting t-GMP′s dynamic role in cellular processes. In adult rat epididymis, t-GMP and c-GMP exhibit a reticular, perinuclear expression pattern, further emphasizing t-GMP′s relevance in tissue-specific functions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

t-GMP Antibody (48A10) References:

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2. Assembly and disassembly of the Golgi complex: two processes arranged in a cis-trans direction.  |  Alcalde, J., et al. 1992. J Cell Biol. 116: 69-83. PMID: 1730750
3. Case-control association study of TGOLN2 in attempted suicide.  |  Mahon, PB., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 1016-23. PMID: 20468057
4. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.  |  Ding, X., et al. 2019. Autophagy. 15: 1774-1786. PMID: 30957628
5. Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.  |  Ponsford, AH., et al. 2021. Autophagy. 17: 1500-1518. PMID: 32515674
6. Two integral membrane proteins located in the cis-middle and trans-part of the Golgi system acquire sialylated N-linked carbohydrates and display different turnovers and sensitivity to cAMP-dependent phosphorylation.  |  Yuan, L., et al. 1987. J Cell Biol. 105: 215-27. PMID: 3301866
7. Integrated Bioinformatics Analysis of the Hub Genes Involved in Irinotecan Resistance in Colorectal Cancer.  |  Kryczka, J. and Boncela, J. 2022. Biomedicines. 10: PMID: 35885025
8. Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation.  |  Zheng, Z., et al. 2023. Autophagy. 19: 3096-3112. PMID: 37471002
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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-t-GMP Antibody (48A10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-t-GMP Antibody (48A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

t-GMP Antibody (48A10) Specifications

Alternate Product Name: t-GMP

Product Clone Name: 48A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: t-GMP

Epitope Species: rat

Product Reactivity/Detection: t-GMP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for t-GMP Antibody (48A10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin