STOP Antibody (296): sc-53512

STOP Antibody (296) is a mouse monoclonal IgG2b antibody that detects STOP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). STOP, or stable tubule only polypeptide, plays a crucial role in the stabilization of microtubules within the cytoplasm of mammalian cells, particularly under conditions that typically promote depolymerization, such as exposure to cold temperatures or assembly-inhibiting drugs. STOP is essential for maintaining the integrity of the cytoskeleton, as STOP allows certain cell types to possess "cold-stable microtubules" that can withstand extreme conditions, including temperatures as low as -80° C. The structure of STOP is noteworthy, featuring a central region with five tandem repeats of 46 amino acids, which contributes to STOP′s ability to stabilize microtubules. Additionally, STOP contains a SH3-binding motif near its N-terminus, which may facilitate interactions with other proteins, further underscoring STOP′s importance in cellular function. The ability of STOP to maintain microtubule stability is vital for various cellular processes, including intracellular transport and cell shape maintenance, making anti-STOP antibody (296) an invaluable tool for researchers studying cytoskeletal dynamics and related cellular mechanisms.

The preferred STOP antibody is STOP Antibody (H-8): sc-137036.