STAP-2 Antibody (E-4): sc-390886
- STAP-2 Antibody (E-4) is a mouse monoclonal IgG2b κ STAP-2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 371-390 near the C-terminus of STAP-2 of human origin
- STAP-2 Antibody (E-4) is recommended for detection of STAP-2 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-STAP-2 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for STAP-2 Antibody (E-4) for WB and IHC(P) applications. These reagents are now offered in bundles with STAP-2 Antibody (E-4) (see ordering information below).
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SEE ALSO...
STAP-2 Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects STAP-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). STAP-2 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STAP-2 protein plays a crucial role in cellular signaling pathways, particularly in tyrosine phosphorylation, which regulates various cellular processes, including cell growth, differentiation, and metabolism. STAP-2 interaction with other proteins, such as BRK (breast tumor kinase), highlights STAP-2′s importance in cancer biology, as BRK is known to be overexpressed in breast tumors and metastatic melanoma cell lines. Pleckstrin homology and SH2 domains in STAP-2 suggest participation in recruiting signaling molecules to membrane sites, thereby influencing downstream signaling cascades. Aberrant regulation of STAP-2 and associated pathways can contribute to tumor progression and metastasis, making STAP-2 a significant target for research in cancer therapeutics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
STAP-2 Antibody (E-4) References:
- Signaling--2000 and beyond. | Hunter, T. 2000. Cell. 100: 113-27. PMID: 10647936
- A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. | Mitchell, PJ., et al. 2000. Oncogene. 19: 4273-82. PMID: 10980601
- Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | Hunter, T. 1995. Cell. 80: 225-36. PMID: 7834742
- Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. | Mitchell, PJ., et al. 1997. Oncogene. 15: 1497-502. PMID: 9333026
- A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation. | Vasioukhin, V. and Tyner, AL. 1997. Proc Natl Acad Sci U S A. 94: 14477-82. PMID: 9405638
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STAP-2 Antibody (E-4) | sc-390886 | 200 µg/ml | $316.00 | |||
STAP-2 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-530296 | 200 µg Ab; 10 µg BP | $354.00 | |||
STAP-2 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-523722 | 200 µg Ab, 40 µg BP | $354.00 | |||
STAP-2 Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-550177 | 200 µg Ab; 10 µg BP | $354.00 | |||
STAP-2 Antibody (E-4) AC | sc-390886 AC | 500 µg/ml, 25% agarose | $416.00 | |||
STAP-2 Antibody (E-4) HRP | sc-390886 HRP | 200 µg/ml | $316.00 | |||
STAP-2 Antibody (E-4) FITC | sc-390886 FITC | 200 µg/ml | $330.00 | |||
STAP-2 Antibody (E-4) PE | sc-390886 PE | 200 µg/ml | $343.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 488 | sc-390886 AF488 | 200 µg/ml | $357.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 546 | sc-390886 AF546 | 200 µg/ml | $357.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 594 | sc-390886 AF594 | 200 µg/ml | $357.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 647 | sc-390886 AF647 | 200 µg/ml | $357.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 680 | sc-390886 AF680 | 200 µg/ml | $357.00 | |||
STAP-2 Antibody (E-4) Alexa Fluor® 790 | sc-390886 AF790 | 200 µg/ml | $357.00 | |||
STAP-2 (E-4) Neutralizing Peptide | sc-390886 P | 100 µg/0.5 ml | $68.00 |