SSX Antibody (C-9): sc-137073

SSX Antibody (C-9) is a mouse monoclonal IgG2b antibody that detects SSX in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SSX, or synovial sarcoma translocation protein, plays a critical role in cancer biology as a transcriptional repressor, particularly in synovial sarcomas, where SSX is involved in the t(x;18) chromosomal translocation. This translocation leads to the fusion of SSX with the amino terminus of SYT, resulting in the formation of SYT-SSX chimeras that act as potent transcriptional activators. The presence of these chimeras is a hallmark of synovial sarcomas, which account for approximately 10% of soft tissue sarcomas and can be classified into biphasic and monophasic subtypes based on the specific SSX fusion partner involved. Understanding SSX′s role in these cancers is crucial, as SSX not only aids in the diagnosis and classification of synovial sarcomas but also provides insights into potential therapeutic targets. Anti-SSX antibody (C-9) is an invaluable tool for researchers studying the molecular mechanisms underlying synovial sarcoma and the broader implications of SSX in cancer biology.

The preferred SSX antibody is SSX Antibody (C-7): sc-166595.