SSX Antibody (C-7): sc-166595
- SSX Antibody (C-7) is a mouse monoclonal IgG1 κ SSX antibody provided at 200 µg/ml
- raised against amino acids 1-188 representing full length SSX1 of human origin
- SSX Antibody (C-7) is recommended for detection of SSX1, SSX2, SSX3, SSX4, SSX5, SSX6, SSX7, SSX8 and SSX9 of human origin by WB, IP, IF and ELISA
- Anti-SSX Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-166595 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SSX Antibody (C-7) for WB applications. These reagents are now offered in bundles with SSX Antibody (C-7) (see ordering information below).
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SSX Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SSX protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SSX antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SSX protein plays a crucial role as a transcriptional repressor, particularly in synovial sarcoma, where SSX is involved in the t(x;18) translocation that leads to the formation of SYT-SSX fusion proteins. These fusions result in the production of potent transcriptional activators that contribute to tumorigenesis. SSX proteins, classified as cancer/testis antigens, are primarily localized in the nucleus and are expressed in the testis as well as various cancers, making SSX proteins significant targets for cancer immunotherapy. SSX proteins in synovial sarcomas, which account for up to 10% of soft tissue sarcomas, highlight their importance in cancer diagnostics and treatment strategies. Genetic analysis has shown that biphasic synovial sarcomas typically harbor SYT-SSX1 fusions, while monophasic variants are associated with SYT-SSX2 fusions, providing valuable insights into the molecular characterization of these tumors.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SSX Antibody (C-7) References:
- The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. | Nilsson, G., et al. 1999. Cancer Res. 59: 3180-4. PMID: 10397263
- Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. | Crew, AJ., et al. 1995. EMBO J. 14: 2333-40. PMID: 7539744
- Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. | Clark, J., et al. 1994. Nat Genet. 7: 502-8. PMID: 7951320
- Nuclear localization of SYT, SSX and the synovial sarcoma-associated SYT-SSX fusion proteins. | dos Santos, NR., et al. 1997. Hum Mol Genet. 6: 1549-58. PMID: 9285793
- SSX: a multigene family with several members transcribed in normal testis and human cancer. | Gure, AO., et al. 1997. Int J Cancer. 72: 965-71. PMID: 9378559
- SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. | Kawai, A., et al. 1998. N Engl J Med. 338: 153-60. PMID: 9428816
- Expression of SSX genes in human tumors. | Türeci, O., et al. 1998. Int J Cancer. 77: 19-23. PMID: 9639388
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSX Antibody (C-7) | sc-166595 | 200 µg/ml | $322.00 | |||
SSX Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-529001 | 200 µg Ab; 10 µg BP | $361.00 | |||
SSX Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-521671 | 200 µg Ab, 40 µg BP | $361.00 | |||
SSX Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-543259 | 200 µg Ab; 20 µg BP | $361.00 | |||
SSX Antibody (C-7) X | sc-166595 X | 200 µg/0.1 ml | $322.00 | |||
SSX Antibody (C-7) AC | sc-166595 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SSX Antibody (C-7) HRP | sc-166595 HRP | 200 µg/ml | $322.00 | |||
SSX Antibody (C-7) FITC | sc-166595 FITC | 200 µg/ml | $336.00 | |||
SSX Antibody (C-7) PE | sc-166595 PE | 200 µg/ml | $349.00 | |||
SSX Antibody (C-7) Alexa Fluor® 488 | sc-166595 AF488 | 200 µg/ml | $364.00 | |||
SSX Antibody (C-7) Alexa Fluor® 546 | sc-166595 AF546 | 200 µg/ml | $364.00 | |||
SSX Antibody (C-7) Alexa Fluor® 594 | sc-166595 AF594 | 200 µg/ml | $364.00 | |||
SSX Antibody (C-7) Alexa Fluor® 647 | sc-166595 AF647 | 200 µg/ml | $364.00 | |||
SSX Antibody (C-7) Alexa Fluor® 680 | sc-166595 AF680 | 200 µg/ml | $364.00 | |||
SSX Antibody (C-7) Alexa Fluor® 790 | sc-166595 AF790 | 200 µg/ml | $364.00 |