SSTR2 Antibody (A-8): sc-365502

SSTR2 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects SSTR2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-SSTR2 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SSTR2, a member of the somatostatin receptor family, plays a crucial role in mediating the biological effects of somatostatin, a peptide hormone that regulates numerous physiological processes, including hormone secretion, cell proliferation, and neurotransmission. SSTR2 is primarily located on the cell membrane, where SSTR2 functions as a G-protein-coupled receptor, initiating intracellular signaling cascades that can inhibit adenylyl cyclase activity and modulate calcium ion channels. This localization is vital for signal transduction, as SSTR2 effectively responds to somatostatin and regulates various cellular functions. Additionally, SSTR2 can form functional homo- and heterodimers with other somatostatin receptor subtypes, enhancing the complexity and specificity of somatostatin signaling pathways. The presence of SSTR2 in various tissues underscores its importance in both normal physiology and potential pathophysiological conditions, making SSTR2 (A-8) antibody an essential tool for researchers studying somatostatin signaling and its implications in health and disease.

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SSTR2 Antibody (A-8) References:

1. Somatostatin and its receptor family.  |  Patel, YC. 1999. Front Neuroendocrinol. 20: 157-98. PMID: 10433861
2. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.  |  Rocheville, M., et al. 2000. J Biol Chem. 275: 7862-9. PMID: 10713101
3. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.  |  Rocheville, M., et al. 2000. Science. 288: 154-7. PMID: 10753124
4. SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target.  |  Emanuel, O., et al. 2021. Cancers (Basel). 13: PMID: 34638429
5. Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas.  |  Fan, S., et al. 2024. Crit Rev Oncol Hematol. 193: 104223. PMID: 38036157
6. Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors.  |  Kim, JY., et al. 2024. Sci Rep. 14: 4047. PMID: 38374188
7. Cortistatin protects against septic cardiomyopathy by inhibiting cardiomyocyte pyroptosis through the SSTR2-AMPK-NLRP3 pathway.  |  Duan, F., et al. 2024. Int Immunopharmacol. 134: 112186. PMID: 38733824
8. Peptide-guided adaptor-CAR T-Cell therapy for the treatment of SSTR2-expressing neuroendocrine tumors.  |  Pellegrino, C., et al. 2024. Oncoimmunology. 13: 2412371. PMID: 39376579
9. Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype.  |  Patel, YC., et al. 1994. J Biol Chem. 269: 1506-9. PMID: 7904601
10. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness.  |  Reardon, DB., et al. 1997. Mol Endocrinol. 11: 1062-9. PMID: 9212054
11. C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.  |  Sharma, K., et al. 1999. Mol Endocrinol. 13: 82-90. PMID: 9892014
12. Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.  |  Kumar, U., et al. 1999. Diabetes. 48: 77-85. PMID: 9892225

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SSTR2 Antibody (A-8) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-SSTR2 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SSTR2 Antibody (A-8) Specifications

Alternate Product Name: Somatostatin Receptor 2

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 320-369

Epitope Target: SSTR2a

Epitope Species: human

Product Reactivity/Detection: SSTR2a

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for SSTR2 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin