spectrin β II Antibody (G-10): sc-374126
- spectrin β II Antibody (G-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2229-2261 near the C-terminus of spectrin β II of human origin
- recommended for detection of spectrin β II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for spectrin β II Antibody (G-10) for WB applications. These reagents are now offered in bundles with spectrin β II Antibody (G-10) (see ordering information below).
QUICK LINKS
SEE ALSO...
spectrin β II Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects spectrin β II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spectrin β II plays a crucial role in maintaining the structural integrity of the cytoskeleton, particularly in non-erythroid cells, where spectrin β II contributes to the organization and stabilization of the plasma membrane. Spectrin β II is essential for various cellular processes, including the regulation of membrane dynamics and the facilitation of intracellular transport. Notably, spectrin β II interacts with calmodulin in a calcium-dependent manner, which is significant for the calcium-mediated movement of the cytoskeleton at the membrane, thereby influencing cellular signaling and motility. The human SPTBN1 gene, which encodes spectrin β II, is located on chromosome 2p21, highlighting spectrin β II′s importance in both normal cellular function and potential pathophysiological conditions. Anti-spectrin β II antibody (G-10) is an invaluable tool for researchers studying cytoskeletal dynamics and membrane organization in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
spectrin β II Antibody (G-10) References:
- Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site. | Bignone, PA. and Baines, AJ. 2003. Biochem J. 374: 613-24. PMID: 12820899
- Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer. | Jiang, X., et al. 2010. Histol Histopathol. 25: 1497-506. PMID: 20886430
- IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation. | Dai, L., et al. 2013. J Exp Med. 210: 517-34. PMID: 23460728
- βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. | Zhi, X., et al. 2015. Hepatology. 61: 598-612. PMID: 25307947
- Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. | Calabrese, GM., et al. 2017. Cell Syst. 4: 46-59.e4. PMID: 27866947
- SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone. | Xu, X., et al. 2021. Front Cell Dev Biol. 9: 653724. PMID: 33816505
- Revealing the Organ-Specific Expression of SPTBN1 using Single-Cell RNA Sequencing Analysis. | Jung, J. and Wu, Q. 2023. bioRxiv.. PMID: 37333135
- SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma. | Teveroni, E., et al. 2023. Int J Mol Sci. 24: PMID: 38069214
- Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading. | Hagan, ML., et al. 2024. Calcif Tissue Int. 115: 725-743. PMID: 39276238
- Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2). | Lombardo, CR., et al. 1994. J Biol Chem. 269: 29212-9. PMID: 7961888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β II Antibody (G-10) | sc-374126 | 200 µg/ml | $322.00 | |||
spectrin β II Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-537918 | 200 µg Ab; 10 µg BP | $361.00 | |||
spectrin β II Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-535392 | 200 µg Ab; 40 µg BP | $361.00 | |||
spectrin β II Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-545445 | 200 µg Ab; 20 µg BP | $361.00 | |||
spectrin β II (G-10) Neutralizing Peptide | sc-374126 P | 100 µg/0.5 ml | $69.00 |