spectrin β II Antibody (42): sc-136074

spectrin β II Antibody (42) is a mouse monoclonal IgG1 kappa light chain antibody that detects spectrin β II in mouse, rat, human, and canine samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. Anti-spectrin β II antibody (42) is available in a non-conjugated form, allowing for versatile experimental setups. Spectrin β II plays a crucial role in the cytoskeletal architecture of various somatic cells, where spectrin β II contributes to the organization and stabilization of the plasma membrane. Spectrin β II interacts with calmodulin in a calcium-dependent manner, which is essential for the dynamic movement of the cytoskeleton at the membrane, facilitating processes such as secretion and cellular signaling. The human SPTBN1 gene encodes the nonerythroid form of β-spectrin, highlighting spectrin β II′s significance beyond erythrocytes, where spectrin β II is involved in maintaining cellular integrity and function. Anti-spectrin β II antibody (42) enables researchers to gain insights into the cellular mechanisms governed by spectrin β II, enhancing our understanding of its role in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

spectrin β II Antibody (42) References:

1. Patterns of spectrin transcripts in erythroid and non-erythroid cells.  |  Prchal, JT., et al. 1990. J Cell Physiol. 144: 287-94. PMID: 1696273
2. Functional diversity among spectrin isoforms.  |  Coleman, TR., et al. 1989. Cell Motil Cytoskeleton. 12: 225-47. PMID: 2655937
3. The spectrin network as a barrier to lateral diffusion in erythrocytes. A percolation analysis.  |  Saxton, MJ. 1989. Biophys J. 55: 21-8. PMID: 2930822
4. SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.  |  Lin, L., et al. 2021. Theranostics. 11: 4232-4250. PMID: 33754058
5. Heterozygous variants in SPTBN1 cause intellectual disability and autism.  |  Rosenfeld, JA., et al. 2021. Am J Med Genet A. 185: 2037-2045. PMID: 33847457
6. Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.  |  Cousin, MA., et al. 2021. Nat Genet. 53: 1006-1021. PMID: 34211179
7. The present status of erythrocyte spectrin structure: the 106-residue repetitive structure is a basic feature of an entire class of proteins.  |  Speicher, DW. 1986. J Cell Biochem. 30: 245-58. PMID: 3517024
8. Modulation of spectrin-actin assembly by erythrocyte adducin.  |  Gardner, K. and Bennett, V. Nature. 328: 359-62. PMID: 3600811
9. Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression.  |  Wu, H., et al. 2024. J Cell Physiol. 239: 97-111. PMID: 37921259
10. A partial structural repeat forms the heterodimer self-association site of all beta-spectrins.  |  Kennedy, SP., et al. 1994. J Biol Chem. 269: 11400-8. PMID: 8157672
11. Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin.  |  Chang, JG., et al. 1993. Genomics. 17: 287-93. PMID: 8406479
12. The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.  |  Ma, Y., et al. 1993. Brain Res Mol Brain Res. 18: 87-99. PMID: 8479293

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-spectrin β II Antibody (42) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-spectrin β II Antibody (42) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

spectrin β II Antibody (42) Specifications

Alternate Product Name: spectrin β II

Product Clone Name: 42

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2101-2189

Epitope Target: spectrin β II

Epitope Species: human

Product Reactivity/Detection: spectrin β II

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for spectrin β II Antibody (42): N/A